About: SARS-CoV-2 Causes a Specific Dysfunction of the Kidney Proximal Tubule

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About: SARS-CoV-2 Causes a Specific Dysfunction of the Kidney Proximal Tubule Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	SARS-CoV-2 Causes a Specific Dysfunction of the Kidney Proximal Tubule
Creator	Chen, Zhiyong Miller, Sara Belkhir, Leila De Greef, Julien Laterre, Pierre-François Penaloza, Andrea Pothen, Lucie Yombi, Jean Yildiz, Halil Aydin, Selda Devuyst, Olivier Dewulf, Joseph Gérard, Ludovic Jadoul, Michel Morelle, Johann Perrot, Marie Schmit, Gregory Scohy, Anais Werion, Alexis Wittebole, Xavier Cyr Yombi, Jean
Source	Elsevier; Medline; PMC
abstract	Coronavirus disease 2019 (COVID-19) is commonly associated with kidney damage, and the angiotensin converting enzyme 2 (ACE2) receptor for SARS-CoV-2 is highly expressed in the proximal tubule cells. Whether patients with COVID-19 present specific manifestations of proximal tubule dysfunction remains unknown. To test this, we examined a cohort of 49 patients requiring hospitalization in a large academic hospital in Brussels, Belgium. There was evidence of proximal tubule dysfunction in a subset of patients with COVID-19, as attested by low-molecular-weight proteinuria (70-80%), neutral aminoaciduria (46%), and defective handling of uric acid (46%) or phosphate (19%). None of the patients had normoglycemic glucosuria. Proximal tubule dysfunction was independent of pre-existing comorbidities, glomerular proteinuria, nephrotoxic medications or viral load. At the structural level, kidneys from patients with COVID-19 showed prominent tubular injury, including in the initial part of the proximal tubule, with brush border loss, acute tubular necrosis, intraluminal debris, and a marked decrease in the expression of megalin in the brush border. Transmission electron microscopy identified particles resembling coronaviruses in vacuoles or cisternae of the endoplasmic reticulum in proximal tubule cells. Among features of proximal tubule dysfunction, hypouricemia with inappropriate uricosuria was independently associated with disease severity and with a significant increase in the risk of respiratory failure requiring invasive mechanical ventilation using Cox (adjusted hazard ratio 6.2, 95% CI 1.9-20.1) or competing risks (adjusted sub-distribution hazard ratio 12.1, 95% CI 2.7-55.4) survival models. Thus, our data establish that SARS-CoV-2 causes specific manifestations of proximal tubule dysfunction and provide novel insights into COVID-19 severity and outcome.
has issue date	2020-08-10(xsd:dateTime)
bibo:doi	10.1016/j.kint.2020.07.019
bibo:pmid	32791255
has license	no-cc
sha1sum (hex)	62b193e4bb90f5f4b77bfd669491a01d2558b44b
schema:url	https://doi.org/10.1016/j.kint.2020.07.019
resource representing a document's title	SARS-CoV-2 Causes a Specific Dysfunction of the Kidney Proximal Tubule
has PubMed Central identifier	PMC7416689
has PubMed identifier	32791255
schema:publication	Kidney Int
resource representing a document's body	covid:62b193e4bb90f5f4b77bfd669491a01d2558b44b#body_text
is schema:about of	named entity 'COVID-19' named entity 'Belgium' named entity 'COVID-19' named entity 'low molecular weight' named entity 'uric acid' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'viral load' named entity 'capillary' named entity 'collagenase' named entity 'receptor' named entity 'renin' named entity 'mRNA' named entity 'GraphPad Prism' named entity 'glucosuria' named entity 'post-mortem interval' named entity 'kidney' named entity 'anti-cancer' named entity 'vacuolar' named entity 'polyacrylamide gel electrophoresis' named entity 'Sub-Saharan African' named entity 'SARS-CoV-2' named entity 'complement' named entity 'megalin' named entity 'Brussels' named entity 'urinalyses' named entity 'hematoxylin' named entity 'electronic medical records' named entity 'antiviral' named entity 'lysis' named entity 'acute tubular necrosis' named entity 'excretion' named entity 'ACE2' named entity 'type 2 diabetes' named entity 'optical level' named entity 'SARS-Cov-2' named entity 'glucosuria' named entity 'invasive mechanical ventilation' named entity 'creatinine' named entity 'proximal tubule' named entity 'sodium dodecylsulfate' named entity 'AKI' named entity 'primary antibody' named entity 'ACE2' named entity 'intensive care unit' named entity 'infection' named entity 'brush border' named entity 'Belgium' named entity 'ACE2' named entity 'Kidneys' named entity 'kidney cells' named entity 'Cliniques universitaires Saint-Luc' named entity 'Invasive mechanical ventilation' named entity 'apical membrane' named entity 'formaldehyde' named entity 'polyacrylamide gel electrophoresis' named entity 'virus' named entity 'COVID' named entity 'kidney' named entity 'acute kidney injury' named entity 'morphology'

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