About: Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of Macrophages

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About: Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of Macrophages Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of Macrophages
Creator	Navas-Martin, Sonia Ikpeze, Nneka Martin-Garcia, Julio Mazaleuskaya, Liudmila Veltrop, Rogier
Source	Medline; PMC
abstract	Toll-like Receptors (TLRs) sense viral infections and induce production of type I interferons (IFNs), other cytokines, and chemokines. Viral recognition by TLRs and other pattern recognition receptors (PRRs) has been proven to be cell-type specific. Triggering of TLRs with selected ligands can be beneficial against some viral infections. Macrophages are antigen-presenting cells that express TLRs and have a key role in the innate and adaptive immunity against viruses. Coronaviruses (CoVs) are single-stranded, positive-sense RNA viruses that cause acute and chronic infections and can productively infect macrophages. Investigation of the interplay between CoVs and PRRs is in its infancy. We assessed the effect of triggering TLR2, TLR3, TLR4, and TLR7 with selected ligands on the susceptibility of the J774A.1 macrophage cell line to infection with murine coronavirus (mouse hepatitis virus, [MHV]). Stimulation of TLR2, TLR4, or TLR7 did not affect MHV production. In contrast, pre-stimulation of TLR3 with polyinosinic-polycytidylic acid (poly I:C) hindered MHV infection through induction of IFN-β in macrophages. We demonstrate that activation of TLR3 with the synthetic ligand poly I:C mediates antiviral immunity that diminishes (MHV-A59) or suppresses (MHV-JHM, MHV-3) virus production in macrophages.
has issue date	2012-05-24(xsd:dateTime)
bibo:doi	10.3390/v4050901
bibo:pmid	22754655
has license	cc-by
sha1sum (hex)	62f5729ba9ae176c206cafd0221804a80772ea37
schema:url	https://doi.org/10.3390/v4050901
resource representing a document's title	Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of Macrophages
has PubMed Central identifier	PMC3386628
has PubMed identifier	22754655
schema:publication	Viruses
resource representing a document's body	covid:62f5729ba9ae176c206cafd0221804a80772ea37#body_text
is schema:about of	named entity 'MURINE CORONAVIRUS' named entity 'TYPE I INTERFERON' named entity 'TOLL-LIKE RECEPTOR 3' named entity 'PROTECTIVE ROLE' named entity 'CORONAVIRUS INFECTION' named entity 'TLR3' named entity 'TYPE I INTERFERONS' named entity 'CHRONIC INFECTIONS' named entity 'EFFECT' named entity 'J774A.1' named entity 'POLYINOSINIC-POLYCYTIDYLIC ACID' named entity 'SENSE' named entity 'VIRUSES' named entity 'DID' named entity 'CONTRAST' named entity 'PRE' named entity 'INVESTIGATION' named entity 'INDUCED' named entity 'MACROPHAGES' named entity 'INTERFERON ' named entity 'CORONAVIRUSES' named entity 'TRIGGERING' named entity 'SUSCEPTIBILITY' named entity 'AFFECT' named entity 'HAVE' named entity 'MACROPHAGE CELL LINE' named entity 'SINGLE' named entity 'KEY' named entity 'TOLL-LIKE RECEPTORS' named entity 'ADAPTIVE IMMUNITY' named entity 'LIGANDS' named entity 'PROVEN' named entity 'TLR7' named entity 'INFANCY' named entity 'EXPRESS' named entity 'SPECIFIC' named entity 'VIRAL' named entity 'CYTOKINES' named entity 'PATTERN RECOGNITION RECEPTORS' named entity 'IFN' named entity 'HEPATITIS VIRUS' named entity 'ITS' named entity 'SELECTED' named entity 'MACROPHAGES' named entity 'PRODUCTION' named entity 'INFECT' named entity 'TLR4' named entity 'BENEFICIAL' named entity 'MURINE CORONAVIRUS' named entity 'RECOGNITION' named entity 'VIRAL INFECTIONS' named entity 'STIMULATION' named entity 'BE CELL' named entity 'PRRS' named entity 'INFECTION' named entity 'ACUTE' named entity 'INDUCTION' named entity 'ASSESSED' named entity 'ACTIVATION' named entity 'MHV' named entity 'ROLE' named entity 'ANTIGEN-PRESENTING CELLS' named entity 'LIGAND' named entity 'CHEMOKINES' named entity 'CAUSE' named entity 'INDUCE' named entity 'TYPE' named entity 'TLR2' named entity 'POSITIVE-SENSE RNA VIRUSES' named entity 'SYNTHETIC' named entity 'COVS' covid:arg/62f5729ba9ae176c206cafd0221804a80772ea37 named entity 'TLR4' named entity 'TLR7' named entity 'PRRs' named entity 'TLR3' named entity 'Coronaviruses'

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