About: M(IL-4) Tissue Macrophages Support Efficient Interferon-Gamma Production in Antigen-Specific CD8(+) T Cells with Reduced Proliferative Capacity

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About: M(IL-4) Tissue Macrophages Support Efficient Interferon-Gamma Production in Antigen-Specific CD8(+) T Cells with Reduced Proliferative Capacity Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	M(IL-4) Tissue Macrophages Support Efficient Interferon-Gamma Production in Antigen-Specific CD8(+) T Cells with Reduced Proliferative Capacity
Creator	Banete, Andra Basta, Sameh Mulder, Rylend Seaver, Kyle Leo, Oberdan Lugo-Villarino, Geanncarlo Tabouret, Guillaume
source	Medline; PMC
abstract	CD8(+) cytotoxic T cell (CTL) responses are necessary for the lysis of virally infected cells and control of infection. CTLs are activated when their TCRs bind a major histocompatibility complex (MHC)-I/peptide complex on the surface of antigen presenting cells such as macrophages (MΦ). It is now apparent that MΦ display remarkable plasticity in response to environmental signals to polarize into classically activated M(LPS + IFN-γ) or alternatively activated M(IL-4). However, little is known about how MΦ activation status influences their antigen presentation function to CD8(+) T cell in models of virus infection. Consequently, we tested how polarization of spleen-derived (Sp)-MΦ impacts direct presentation of viral antigens to influence effector and proliferative CD8(+) T-cell responses. We show that M(IL-4) Sp-MΦ retain MHC-I surface expression and the ability to stimulate IFN-γ production by CTL following peptide stimulation and lymphocytic choriomeningitis virus infection to levels similar to M0 and M(LPS + IFN-γ) MΦ. However, memory CD8(+) T cells cultured in the presence of M(IL-4) MΦ underwent significantly reduced proliferation and produced similar IFN-γ levels as coculturing with M0 or M(LPS + IFN-γ) cells. Thus, these results show a novel ability of polarized MΦ to regulate CD8(+) T-cell proliferation and effector functions during virus infection.
has issue date	2017-11-30(xsd:dateTime)
bibo:doi	10.3389/fimmu.2017.01629
bibo:pmid	29250063
has license	cc-by
sha1sum (hex)	6387603fb5f8eda220411438a86234c475aa728e
schema:url	https://doi.org/10.3389/fimmu.2017.01629
resource representing a document's title	M(IL-4) Tissue Macrophages Support Efficient Interferon-Gamma Production in Antigen-Specific CD8(+) T Cells with Reduced Proliferative Capacity
has PubMed Central identifier	PMC5714867
has PubMed identifier	29250063
schema:publication	Front Immunol
resource representing a document's body	covid:6387603fb5f8eda220411438a86234c475aa728e#body_text
is schema:about of	named entity 'IFN-γ' named entity 'presence' named entity 'LPS' named entity 'proliferative' named entity 'major histocompatibility complex (MHC)' named entity 'lysis' covid:arg/6387603fb5f8eda220411438a86234c475aa728e named entity 'cultured' named entity 'effector' named entity 'IL-4' named entity 'TCRs' named entity 'viral antigens' named entity 'polarized' named entity 'responses' named entity 'polarize' named entity 'peptide' named entity 'bind' named entity 'plasticity' named entity 'impacts' named entity 'virus infection' named entity 'lymphocytic choriomeningitis virus' named entity 'effector' named entity 'cytotoxic T cell' named entity 'T-cell' named entity 'lysis' named entity 'interferon-gamma' named entity 'Tissue Macrophages' named entity 'infection' named entity 'monoclonal antibody' named entity 'hepatitis C virus (HCV) infection' named entity 'peptides' named entity 'IL-12p40' named entity 't-test' named entity 'molarity' named entity 'CD8 +' named entity 'CD8 +' named entity 'IL-2' named entity 'molarity' named entity 'infection' named entity 'CTL' named entity 'molarity' named entity 'CD3' named entity 'secretion' named entity 'LCMV' named entity 'T-cell' named entity 'Z Buffer' named entity 'T-cell' named entity 'infection' named entity 'cyclin-dependent kinase 4' named entity 'IL-2' named entity 'IL-4' named entity 'cytokine' named entity 'CD8 +' named entity 'IL-2' named entity 'IL-4' named entity 'MHC-I' named entity 'oncogenes' named entity 'PBS' named entity 'LCMV' named entity 'VL4' named entity 'T-cell' named entity 'IL-4' named entity 'protein' named entity 'IL-4' named entity 'leukemia' named entity 'polarization' named entity 'molarity' named entity 'mononuclear phagocyte' named entity 'Peptide' named entity 'antigen' named entity 'CD80' named entity 'NFAT' named entity 'molarity' named entity 'cell line' named entity 'ligands'

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