About: Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate

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About: Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate
Creator	Zhang, Jing Zhang, Qiwei Zeng, Zhiwei Chodosh, James Yu, Nan Che, Xiaoyan Fu, Ning Chen, Manjun Guo, Yonghui Pan, Yuxian Yu, Zhiwu
source	Medline; PMC
abstract	Human adenoviruses (HAdVs) are highly contagious pathogens causing acute respiratory disease (ARD), such as community-acquired pneumonia. HAdV-7d, a re-emergent genomic variant, has been recently reported in Asia and the United States after a several-decade absence. However, whether HAdV-7d is associated with higher severity than other types is currently unclear. In this study, the clinical and epidemiological investigation showed that fever, cough, and sore throat were the three most common respiratory symptoms of HAdV infections. HAdV-7 caused longer duration of fever, higher morbidity of tachypnea/dyspnea, pleural effusion, diarrhea, hepatosplenomegaly, consciousness alteration, as well as higher rates of pneumonia, mechanical ventilation and higher fatality rate (28.6%) than other types, particularly HAdV-3 and HAdV-2. The genomes of seven HAdV-7d isolates from mild, severe, and fatal cases were sequenced and highly similar with each other. Surprisingly, two isolates (2011, 2012) had 100% identical genomes with an earlier strain from a fatal ARD outbreak in China (2009), which elucidates the virus origin and confirms the unexpected HAdV genomic conservation and stability. Phylogenetic analysis indicated that L1 52/55-kDa DNA packaging protein may be associated with the higher severity of illness and fatality rate of HAdV-7. Clinicians need to be aware of HAdVs in children with ARD.
has issue date	2016-11-16(xsd:dateTime)
bibo:doi	10.1038/srep37216
bibo:pmid	27848998
has license	cc-by
sha1sum (hex)	642e03f3b71051b01c77af78f51bb4ef5d00ad08
schema:url	https://doi.org/10.1038/srep37216
resource representing a document's title	Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate
has PubMed Central identifier	PMC5110970
has PubMed identifier	27848998
schema:publication	Sci Rep
resource representing a document's body	covid:642e03f3b71051b01c77af78f51bb4ef5d00ad08#body_text
is schema:about of	named entity 'Human' named entity 'genomic' named entity 'Adenovirus' named entity 'Higher' named entity 'RATE' named entity 'HIGHER' named entity 'RATES' covid:arg/642e03f3b71051b01c77af78f51bb4ef5d00ad08 named entity 'NEED' named entity 'EARLIER' named entity 'ORIGIN' named entity 'HUMAN' named entity 'ISOLATES' named entity 'GENOMIC' named entity 'MORBIDITY' named entity 'PLEURAL EFFUSION' named entity 'CAUSING' named entity 'CHINA' named entity 'RECENTLY' named entity 'UNEXPECTED' named entity 'TYPES' named entity 'CONSERVATION' named entity 'COMMON' named entity 'CURRENTLY' named entity 'PHYLOGENETIC ANALYSIS' named entity 'SEVERITY' named entity 'HIGHLY' named entity 'FATAL' named entity 'MILD' named entity 'EMERGENT' named entity 'CLINICIANS' named entity 'ALTERATION' named entity 'VIRUS' named entity 'SEVERE' named entity 'OUTBREAK' named entity 'COUGH' named entity 'FEVER' named entity 'FATAL' named entity 'ASSOCIATED WITH' named entity 'CASES' named entity 'ACUTE RESPIRATORY DISEASE' named entity 'ABSENCE' named entity 'HUMAN ADENOVIRUS' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'CAUSED BY' named entity 'EMERGENT' named entity 'CHILDREN' named entity 'SEVERITY OF ILLNESS' named entity 'PNEUMONIA' named entity 'HEPATOSPLENOMEGALY' named entity 'TACHYPNEA' named entity 'DECADE' named entity 'CONFIRMS' named entity 'MAY BE' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'CLINICAL' named entity 'ADENOVIRUSES' named entity 'UNCLEAR' named entity 'SORE THROAT' named entity 'IDENTICAL' named entity 'AWARE' named entity 'RATE' named entity 'CHILDREN' named entity 'SIMILAR' named entity 'INDICATED' named entity 'CAUSED' named entity 'RESPIRATORY SYMPTOMS' named entity 'STABILITY' named entity 'INVESTIGATION' named entity 'CONSCIOUSNESS' named entity 'UNITED STATES'

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