About: Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections

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About: Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections
Creator	Huang, Angela Faron, Matthew Leber, Amy Everhart, Kathy Harrington, Amanda Ledeboer, Nathan Balada-Llasat, Joan-Miquel Kwong, Christina Naccache, Samia Relich, Ryan Humphries, Romney Bard, Jennifer Buchan, Blake Akerele, Oluseun Bonwit, Andrew Buckner, Rebecca Carroll, Amanda Chandrasekaran, Sukantha Fowler, Randal Graue, Corrin Hopp, Amanda Huse, Holly Murphy, Caitlin Ronen, Shira Campeau, Shelley Warren, Del Windham, Sam Mahmutoglu, Derya Stone, Hannah Bard, Dien Bw, Buchan Kwong, Bonwit Na, Carroll
source	PMC
abstract	Lower respiratory tract infections, including hospital-acquired and ventilator-associated pneumonia, are common in hospitalized patient populations. Standard methods frequently fail to identify the infectious etiology due to the polymicrobial nature of respiratory specimens and the necessity of ordering specific tests to identify viral agents. The potential severity of these infections combined with a failure to clearly identify the causative pathogen results in administration of empirical antibiotic agents based on clinical presentation and other risk factors. We examined the impact of the multiplexed, semiquantitative BioFire FilmArray Pneumonia panel (PN panel) test on laboratory reporting for 259 adult inpatients submitting bronchoalveolar lavage (BAL) specimens for laboratory analysis. The PN panel demonstrated a combined 96.2% positive percent agreement (PPA) and 98.1% negative percent agreement (NPA) for the qualitative identification of 15 bacterial targets compared to routine bacterial culture. Semiquantitative values reported by the PN panel were frequently higher than values reported by culture, resulting in semiquantitative agreement (within the same log(10) value) of 43.6% between the PN panel and culture; however, all bacterial targets reported as >10(5) CFU/ml in culture were reported as ≥10(5) genomic copies/ml by the PN panel. Viral targets were identified by the PN panel in 17.7% of specimens tested, of which 39.1% were detected in conjunction with a bacterial target. A review of patient medical records, including clinically prescribed antibiotics, revealed the potential for antibiotic adjustment in 70.7% of patients based on the PN panel result, including discontinuation or de-escalation in 48.2% of patients, resulting in an average savings of 6.2 antibiotic days/patient.
has issue date	2020-06-24(xsd:dateTime)
bibo:doi	10.1128/jcm.00135-20
bibo:pmid	32350045
has license	cc-by
sha1sum (hex)	6477aba88b3d95cc75bda3e293cab9ac622d3c0f
schema:url	https://doi.org/10.1128/jcm.00135-20
resource representing a document's title	Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections
has PubMed Central identifier	PMC7315039
has PubMed identifier	32350045
schema:publication	J Clin Microbiol
resource representing a document's body	covid:6477aba88b3d95cc75bda3e293cab9ac622d3c0f#body_text
is schema:about of	named entity 'respiratory' named entity 'antibiotic' named entity 'NPA' named entity 'culture' named entity 'pathogen' named entity 'result' named entity 'ventilator-associated pneumonia' named entity 'identify' named entity 'targets' named entity 'bacterial' named entity 'bacterial' named entity 'patients' named entity 'infections' named entity 'antibiotic' named entity 'saline' named entity 'Maywood, IL' named entity 'etiologies' named entity 'S. marcescens' named entity 'pure culture' named entity 'Omaha' named entity 'broad-spectrum' named entity 'SOC' named entity 'antimicrobial' named entity 'antibiotic' named entity 'culture results' named entity 'PCR' named entity 'identified' named entity 'specimens' named entity 'identify' named entity 'nature' named entity 'targets' named entity 'culture' named entity 'Comparison' named entity 'medical records' named entity 'antibiotic' named entity 'laboratory analysis' named entity 'Pneumonia' named entity 'Lower Respiratory Tract Infections' named entity 'medical records' named entity 'antibiotic therapy' named entity 'Morganella morganii' named entity 'antibiotic' named entity 'pathogens' named entity 'pathogen' named entity 'pathogens' named entity 'antibiotic' named entity 'LIS' named entity 'B virus' named entity 'influenza'

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