About: H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2
Creator	Wang, Hua Huang, Ying Chen, Xi Wang, Jin Qi, Xian Liu, Fenyong Li, Limin Ding, Meng Fu, Zheng Gu, Hongwei Li, Donghai Li, Xihan Liang, Hongwei Sun, Xinlei Wang, Yanbo Zen, Ke Zhang, Chen-Yu Zhao, Quan Zhou, Zhen
source	PMC
abstract	Infection of H5N1 influenza virus causes the highest mortality among all influenza viruses. The mechanisms underlying such high viral pathogenicity are incompletely understood. Here, we report that the H5N1 influenza virus encodes a microRNA-like small RNA, miR-HA-3p, which is processed from a stem loop-containing viral RNA precursor by Argonaute 2, and plays a role in enhancing cytokine production during H5N1 infection. Mechanistic study shows that miR-HA-3p targets poly(rC)-binding protein 2 (PCBP2) and suppresses its expression. Consistent with PCBP2 being an important negative regulator of RIG-I/MAVS-mediated antiviral innate immunity, suppression of PCBP2 expression by miR-HA-3p promotes cytokine production in human macrophages and mice infected with H5N1 virus. We conclude that miR-HA-3p is the first identified influenza virus-encoded microRNA-like functional RNA fragment and a novel virulence factor contributing to H5N1-induced 'cytokine storm' and mortality.
has issue date	2018-01-12(xsd:dateTime)
bibo:doi	10.1038/cr.2018.3
bibo:pmid	29327729
has license	cc-by
sha1sum (hex)	64c4f7c5aae70b4cb5d4802fdf363bb7b716d50b
schema:url	https://doi.org/10.1038/cr.2018.3
resource representing a document's title	H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2
has PubMed Central identifier	PMC5799819
has PubMed identifier	29327729
schema:publication	Cell Res
resource representing a document's body	covid:64c4f7c5aae70b4cb5d4802fdf363bb7b716d50b#body_text
is schema:about of	named entity 'cursor' named entity 'influenza' named entity 'induced' named entity 'influenza' named entity 'human' named entity 'H5N1' named entity 'mice' named entity 'cytokine' named entity 'antiviral' named entity 'RIG-I' named entity 'incompletely' named entity 'binding' named entity 'H5N1' named entity 'targeting' named entity 'virus' named entity 'Consistent' named entity 'small RNA' named entity 'Mechanistic' named entity 'virus' named entity 'H5N1' named entity 'binding protein' named entity 'macrophages' named entity 'RIG-I' named entity 'pathogenicity' named entity 'influenza virus' named entity 'infection' named entity 'innate immunity' named entity 'miR' named entity 'miR' named entity 'cytokine' named entity 'virulence factor' named entity 'viral RNA' named entity 'influenza virus' named entity 'influenza virus' named entity 'functional RNA' named entity 'cytokine storm' named entity 'survival rate' named entity 'RNA virus' named entity 'neutrophil' named entity 'H5N1' named entity 'antagomir' named entity 'wild-type' named entity 'antagomir' named entity 'immunoprecipitate' named entity 'rHu' named entity 'innate immune' named entity 'miR' named entity 'transcription' named entity 'negative-sense, single-stranded RNA' named entity 'ssRNA' named entity 'mice' named entity 'downregulated' named entity 'H5N1' named entity 'Ago2' named entity 'serum' named entity 'macrophages' named entity 'reference genome' named entity 'H5N1' named entity 'miR' named entity 'saline' named entity 'miR' named entity 'H5N1' named entity 'Jiangsu'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software