About: Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors

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About: Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors
Creator	Kao, Chuan-Liang Wang, Wei-Kung Liu, I-Jung Hsieh, Szu-Chia Kan, Lon-Sing Wang, W.-K Wey, Ming-Tsair
Source	Elsevier; Medline; PMC
abstract	Abstract The heptad repeats (HR1 and HR2) of the spike protein of SARS-CoV are highly conserved regions forming a critical 6-helix bundle during the fusion step of virus entry and are attractive targets of entry inhibitors. In this study, we report that a minimal HR2 peptide, P6 of 23-mer, can block the fusion of SARS-CoV with an IC50 of 1.04±0.22μM. This finding supports the structural prediction of the deep groove of HR1 trimer as a target for fusion inhibitors, and suggests P6 as a potential lead peptide for future drug development. Moreover, combination of an HR-1 peptide, N46, and its mutated version, N46eg, shows synergistic inhibition with an IC50 of 1.39±0.05μM and combination index of 0.75±0.15, suggesting a common strategy to achieve promising inhibition by HR1 peptide for other class I envelope viruses.
has issue date	2009-01-31(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2008.10.001
bibo:pmid	18983873
has license	els-covid
sha1sum (hex)	65ef6e86fee8614485fd93ebe26e219e4f0d7f05
schema:url	https://doi.org/10.1016/j.antiviral.2008.10.001
resource representing a document's title	Identification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors
has PubMed Central identifier	PMC7114320
has PubMed identifier	18983873
schema:publication	Antiviral Research
resource representing a document's body	covid:65ef6e86fee8614485fd93ebe26e219e4f0d7f05#body_text
is schema:about of	named entity 'drug development' named entity 'mutated' named entity 'targets' named entity 'deep' named entity 'HR1' named entity 'Identification' named entity 'SARS-COV' named entity 'CRITICAL' named entity 'FUSION' named entity 'FUSION INHIBITORS' named entity 'PEPTIDE' named entity 'FUSION INHIBITORS' named entity 'MINIMAL' named entity 'FINDING' named entity 'LEAD' named entity 'HR2' named entity '1.39' named entity 'HELIX' named entity 'INHIBITION' named entity 'BUNDLE' named entity 'STRUCTURAL' named entity 'TRIMER' named entity 'HR1' named entity 'DRUG DEVELOPMENT' named entity '0.75' named entity 'STRATEGY' named entity 'N46' named entity 'ENVELOPE' named entity 'CLASS I' named entity 'REGIONS' named entity 'SARS-COV' named entity 'HIGHLY' named entity 'MUTATED' named entity 'PEPTIDES' named entity 'IDENTIFICATION' named entity 'REPORT' named entity 'TARGET' named entity 'MER' named entity 'VIRUS ENTRY' named entity 'DERIVED' named entity 'COMBINATION' named entity 'PROTEIN ' named entity 'REPEAT' named entity 'SPIKE PROTEIN' named entity 'REPEATS' named entity 'POTENTIAL' named entity 'INDEX' named entity 'BLOCK' named entity 'HR1' named entity 'ATTRACTIVE' named entity 'STUDY' named entity '0.05' named entity 'SPIKE PROTEIN' named entity 'ITS' named entity '0.15' named entity 'TARGETS' named entity 'PREDICTION' named entity 'CONSERVED' named entity 'FORMING' named entity '1.04' named entity 'COMBINATION' named entity 'STEP' named entity 'VIRUSES' named entity 'PEPTIDE' named entity 'ENTRY INHIBITORS' named entity 'FUTURE' named entity 'VERSION' named entity 'THE DEEP' named entity 'A COMMON' named entity 'GROOVE' named entity 'MINIMAL' named entity 'PROTEIN ' named entity 'SYNERGISTIC' covid:arg/65ef6e86fee8614485fd93ebe26e219e4f0d7f05 named entity 'peptide'

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