About: Antiviral activity of four types of bioflavonoid against dengue virus type-2

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About: Antiviral activity of four types of bioflavonoid against dengue virus type-2 Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral activity of four types of bioflavonoid against dengue virus type-2
Creator	Zandi, Keivan Sam, Sing-Sin Teoh, Boon-Teong Wong, Pooi-Fong Abubakar, Sazaly Mustafa, Mohd
Source	Medline; PMC
abstract	BACKGROUND: Dengue is a major mosquito-borne disease currently with no effective antiviral or vaccine available. Effort to find antivirals for it has focused on bioflavonoids, a plant-derived polyphenolic compounds with many potential health benefits. In the present study, antiviral activity of four types of bioflavonoid against dengue virus type -2 (DENV-2) in Vero cell was evaluated. Anti-dengue activity of these compounds was determined at different stages of DENV-2 infection and replication cycle. DENV replication was measured by Foci Forming Unit Reduction Assay (FFURA) and quantitative RT-PCR. Selectivity Index value (SI) was determined as the ratio of cytotoxic concentration 50 (CC(50)) to inhibitory concentration 50 (IC(50)) for each compound. RESULTS: The half maximal inhibitory concentration (IC(50)) of quercetin against dengue virus was 35.7 μg mL(-1 )when it was used after virus adsorption to the cells. The IC(50 )decreased to 28.9 μg mL(-1 )when the cells were treated continuously for 5 h before virus infection and up to 4 days post-infection. The SI values for quercetin were 7.07 and 8.74 μg mL(-1), respectively, the highest compared to all bioflavonoids studied. Naringin only exhibited anti-adsorption effects against DENV-2 with IC(50 )= 168.2 μg mL(-1 )and its related SI was 1.3. Daidzein showed a weak anti-dengue activity with IC(50 )= 142.6 μg mL(-1 )when the DENV-2 infected cells were treated after virus adsorption. The SI value for this compound was 1.03. Hesperetin did not exhibit any antiviral activity against DENV-2. The findings obtained from Foci Forming Unit Reduction Assay (FFURA) were corroborated by findings of the qRT-PCR assays. Quercetin and daidzein (50 μg mL(-1)) reduced DENV-2 RNA levels by 67% and 25%, respectively. There was no significant inhibition of DENV-2 RNA levels with naringin and hesperetin. CONCLUSION: Results from the study suggest that only quercetin demonstrated significant anti-DENV-2 inhibitory activities. Other bioflavonoids, including daidzein, naringin and hesperetin showed minimal to no significant inhibition of DENV-2 virus replication. These findings, together with those previously reported suggest that select group of bioflavonoids including quercetin and fisetin, exhibited significant inhibitory activities against dengue virus. This group of flavonoids, flavonol, could be investigated further to discover the common mechanisms of inhibition of dengue virus replication.
has issue date	2011-12-28(xsd:dateTime)
bibo:doi	10.1186/1743-422x-8-560
bibo:pmid	22201648
has license	cc-by
sha1sum (hex)	6652151e876145926c6b4c6d683346811588bdfa
schema:url	https://doi.org/10.1186/1743-422x-8-560
resource representing a document's title	Antiviral activity of four types of bioflavonoid against dengue virus type-2
has PubMed Central identifier	PMC3271998
has PubMed identifier	22201648
schema:publication	Virol J
resource representing a document's body	covid:6652151e876145926c6b4c6d683346811588bdfa#body_text
is schema:about of	named entity 'POTENTIAL' named entity 'RNA' named entity 'VIRUS INFECTION' named entity 'DENV-2' named entity 'FINDINGS' named entity 'COMPARED' named entity 'DAIDZEIN' named entity 'HALF MAXIMAL INHIBITORY CONCENTRATION' named entity 'RESULTS' named entity 'DETERMINED' named entity 'REDUCED' named entity 'RELATED' named entity 'BORNE' named entity 'PLANT-' named entity 'OBTAINED' named entity 'VIRUS TYPE' named entity 'MEASURED' named entity 'HIGHEST' named entity 'VALUE' named entity 'EXHIBIT' named entity 'CELLS' named entity 'INFECTION' named entity 'antiviral' named entity 'cell' named entity 'focused' named entity 'infection' named entity 'Antiviral' named entity 'BIOFLAVONOID' named entity 'FOCUSED' named entity 'AVAILABLE' named entity 'INHIBITORY CONCENTRATION 50' named entity 'CURRENTLY' named entity 'VERO CELL' named entity 'REPLICATION' named entity 'COMPOUND' named entity 'EFFECTIVE' named entity 'IS A' named entity 'QUERCETIN' named entity 'REDUCTION' named entity 'BIOFLAVONOID' named entity 'STUDY' named entity 'USED' named entity 'ASSAY' named entity 'INDEX VALUE' named entity 'FORMING' named entity 'HEALTH BENEFITS' named entity 'ANTIVIRAL ACTIVITY' named entity 'BACKGROUND' named entity 'VALUES' named entity 'A MAJOR' named entity 'TREATED' named entity 'UP TO' named entity 'FOCI' named entity 'VACCINE' named entity 'DAYS' named entity 'SELECTIVITY' named entity 'DIFFERENT' named entity 'LEVELS' named entity 'DID' named entity 'THESE' named entity 'DERIVED' named entity '1.3' named entity 'UNIT' named entity 'QUANTITATIVE RT-PCR' named entity 'EVALUATED' named entity 'ANTIVIRAL ACTIVITY' named entity 'DENGUE' named entity 'ANTIVIRALS' named entity 'STAGES' named entity 'POST' named entity 'TYPES' named entity 'DENGUE VIRUS' named entity 'VIRUS TYPE' named entity 'QRT-PCR' named entity 'DISEASE' named entity 'ACTIVITY'

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