About: Evaluation of safety, humoral immune response and faecal shedding in horses inoculated with a modified‐live bovine coronavirus vaccination

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About: Evaluation of safety, humoral immune response and faecal shedding in horses inoculated with a modified‐live bovine coronavirus vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Evaluation of safety, humoral immune response and faecal shedding in horses inoculated with a modified‐live bovine coronavirus vaccination
Creator	Pusterla, N Barnum, S Prutton, J
source	Medline; PMC
abstract	Equine coronavirus (ECoV) is considered an emerging enteric virus with reported morbidity rates ranging from 10 to 83% and fatality rates ranging from 7 to 27% in adult horses; a vaccine for ECoV is currently not available. This study investigated the safety, humoral response and viral shedding in horses inoculated with a commercially available modified‐live bovine coronavirus (BCoV) vaccine. Twelve healthy adult horses were vaccinated twice, 3 weeks apart, either orally, intranasally or intrarectally. Two healthy unvaccinated horses served as sentinel controls. Following each vaccine administration, horses were monitored daily for physical abnormalities whilst the onset and duration of BCoV shedding was determined by quantitative PCR (qPCR) in nasal secretions and faeces. Whole blood was collected every 3 weeks to determine BCoV‐specific antibody response. With the exception of transient and self‐limiting changes in faecal character observed in seven vaccinated and one control horse, no additional abnormal clinical findings were found in the study horses. Following the first and second vaccine administration, two and one horse, respectively, tested qPCR‐positive for BCoV in nasal secretions 1‐day post intranasal vaccination. No vaccinated horses tested qPCR‐positive for BCoV in faeces following each vaccine administration. One of the two horses that shed BCoV seroconverted to BCoV after the first vaccine administration and an additional two vaccinated horses (oral and intrarectal) seroconverted to BCoV after the second vaccine administration. In conclusion, the results show that the modified‐live BCoV is safe to administer to horses via various routes, causes minimal virus shedding and results in detectable antibodies to BCoV in 27% of the vaccinates.
has issue date	2019-08-31(xsd:dateTime)
bibo:doi	10.1111/eve.13175
bibo:pmid	32427191
has license	no-cc
sha1sum (hex)	66c0d25c0796550cfe47a99742ddfa3eb2a9b4fd
schema:url	https://doi.org/10.1111/eve.13175
resource representing a document's title	Evaluation of safety, humoral immune response and faecal shedding in horses inoculated with a modified‐live bovine coronavirus vaccination
has PubMed Central identifier	PMC7228322
has PubMed identifier	32427191
schema:publication	Equine Vet Educ
resource representing a document's body	covid:66c0d25c0796550cfe47a99742ddfa3eb2a9b4fd#body_text
is schema:about of	named entity 'nasal secretions' named entity 'daily' named entity 'monitored' named entity 'vaccinated' named entity 'administration' named entity 'shedding' named entity 'FAECAL' named entity 'ANTIBODIES' named entity 'VACCINE ADMINISTRATION' named entity 'HEALTHY ADULT' named entity 'WHOLE BLOOD' named entity 'ADULT' named entity 'tested' named entity 'self-limiting' named entity 'intranasal' named entity 'inoculated' named entity 'duration' named entity 'response' named entity 'fatality' named entity 'One' named entity 'horses' named entity 'emerging' named entity 'administration' named entity 'tested' named entity 'administration' named entity 'Whole blood' named entity 'determine' named entity 'modified-live' named entity 'BCoV' named entity 'vaccine' named entity 'morbidity rates' named entity 'vaccination' named entity 'viral shedding' named entity 'BCoV' named entity 'intrarectally' named entity 'modified-live' named entity 'faeces' named entity 'vaccination' named entity 'bovine coronavirus' named entity 'inoculated' named entity 'BCoV' named entity 'modified-live' named entity 'vaccine' named entity 'equine' named entity 'vaccine' named entity 'intrarectal' named entity 'centrifuged' named entity 'lethargy' named entity 'modified-live' named entity 'antigen' named entity 'BCoV' named entity 'diarrhoea' named entity 'antibodies' named entity 'BCoV' named entity 'Lawsonia intracellularis' named entity 'seropositive' named entity 'secondary antibody' named entity 'quality control' named entity 'modified-live' named entity '21 days' named entity 'physical examination' named entity 'BCoV' named entity 'alphacoronavirus' named entity 'oligonucleotides' named entity 'vaccine' named entity 'Seroconversion' named entity 'serum' named entity 'vaccination' named entity 'thermocycler' named entity 'mucosal immunity' named entity 'intrarectally' named entity 'BCoV' named entity 'diarrhoea' named entity 'Veterinary Medicine' named entity 'modified-live' named entity 'viral replication' named entity 'lethargy' named entity 'viral shedding' named entity 'seroconverted'

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