About: Infectious Bronchitis Virus S2 Gene Sequence Variability May Affect S1 Subunit Specific Antibody Binding

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Infectious Bronchitis Virus S2 Gene Sequence Variability May Affect S1 Subunit Specific Antibody Binding
Creator	Jackwood, Mark Callison, Scott Hilt, Deborah
Source	Medline; PMC
abstract	The S2 gene of several strains of infectious bronchitis virus (IBV) belonging to the Arkansas, Connecticut, and Florida serotypes was sequenced. Phylogenetic analysis of the S2 gene nucleotide and deduced amino acid sequence data resulted in groups of strains that were the same as groupings observed when S1 sequence data was used. Thus, it appears that S2 subunits are conserved within a serotype but not between serotypes. Although the sequence differences were small, we found that only a few amino acid differences were responsible for different secondary structure predictions for the S2 subunit. It is likely that these changes create different interactions between the S1 and S2 subunits, which could affect the conformation of the S1 subunit where serotype specific epitopes are located. Based on this sequence data, we hypothesize that the S2 subunit can affect specific antibody binding to the S1 subunit of the IBV spike glycoprotein.
has issue date	1999-01-01(xsd:dateTime)
bibo:doi	10.1023/a:1008179208217
bibo:pmid	10541018
has license	no-cc
sha1sum (hex)	670dddcf5f258783507e2173684f81d55e02ac17
schema:url	https://doi.org/10.1023/a:1008179208217
resource representing a document's title	Infectious Bronchitis Virus S2 Gene Sequence Variability May Affect S1 Subunit Specific Antibody Binding
has PubMed Central identifier	PMC7089226
has PubMed identifier	10541018
schema:publication	Virus Genes
resource representing a document's body	covid:670dddcf5f258783507e2173684f81d55e02ac17#body_text
is schema:about of	named entity 'SUBUNIT' named entity 'CONFORMATION' named entity 'PHYLOGENETIC ANALYSIS' named entity 'WHERE' named entity 'GENE' named entity 'THESE' named entity 'ARKANSAS' named entity 'CHANGES' named entity 'GROUPS' named entity 'INTERACTIONS' named entity 'SEROTYPES' named entity 'SMALL' named entity 'SEQUENCE DATA' named entity 'A SEROTYPE' named entity 'AEC' named entity 'AFFECT' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'CREATE' named entity 'LIKELY' named entity 'RESPONSIBLE' named entity 'FOUND' named entity 'AEC' named entity 'SECONDARY STRUCTURE' named entity 'CONSERVED' named entity 'SUBUNIT' named entity 'EPITOPES' named entity 'AFFECT' named entity 'FLORIDA' named entity 'SEQUENCE' named entity 'STRAINS' named entity 'CONNECTICUT' named entity 'SAME AS' named entity 'BELONGING' named entity 'BUT' named entity 'AMINO ACID SEQUENCE DATA' named entity 'PREDICTIONS' named entity 'NUCLEOTIDE' named entity 'AMINO ACID' named entity 'DIFFERENT' named entity 'BASED' named entity 'USED' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'SEROTYPE' named entity 'OBSERVED' named entity 'VARIABILITY' covid:arg/670dddcf5f258783507e2173684f81d55e02ac17 named entity 'epitopes' named entity 'IBV' named entity 'amino acid' named entity 'serotypes' named entity 'sequenced' named entity 'IBV' named entity 'IBV' named entity 'Infectious bronchitis' named entity 'interact' named entity 'Connecticut' named entity 'secondary structure' named entity 'alanine' named entity 'epitopes' named entity 'gene' named entity 'amino acid sequence' named entity 'viral RNA' named entity 'reverse transcriptase' named entity 'gene' named entity 'MHV' named entity 'Connecticut' named entity 'gene' named entity 'nucleotide sequences' named entity 'Arkansas' named entity 'Connecticut' named entity 'glycoprotein' named entity 'Connecticut' named entity 'amino acid' named entity 'serologically' named entity 'amino acid' named entity 'glycosylated' named entity 'Infectious bronchitis' named entity 'serotype' named entity 'secondary structure prediction'

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