About: A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2

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About: A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2
Creator	Hou, Yixuan Baric, Ralph Gralinski, Lisa Schäfer, Alexandra Zhao, Haiyan Diamond, Michael Case, James Chen, R Curiel, D Curiel, David Dai, Fox, Julie Fremont, Daved Hassan, Ahmed Kim, Arthur Vanblargan, Laura Zhao, H Adams, L Dmitriev, Igor Gralinski, J Hassan, A Holtzman, Michael Mccune, Broc Winkler, Emma Kafai, Natasha Ma, M Bursky, Jane Bailey, A Bailey, Adam Case, J Chen, Rita Fox, J Harvey, Ian Kafai, N Keeler, Shamus Kim, A Shrihari, Swathi Smith, Brittany Weiskopf, Daniela Winkler, E Adams, Lucas Kashentseva, Ma, Meisheng Wessel, Alex Dai, Y.-N Dai, Ya-Nan Danis, Jonathan Dmitriev, I Harvey, B Harvey, I Holtzman, R Kashentseva, E Kashentseva, Elena Keeler, A Schäfer, Y Shrihari, S Vanblargan, L Weiskopf, S Wessel, A
Source	Elsevier; PMC
abstract	Summary The Coronavirus Disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabilized spike protein (ChAd-SARS-CoV-2-S) in challenge studies with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and mice expressing the human angiotensin-converting enzyme 2 receptor. Intramuscular dosing of ChAd-SARS-CoV-2-S induces robust systemic humoral and cell-mediated immune responses and protects against lung infection, inflammation, and pathology but does not confer sterilizing immunity, as evidenced by detection of viral RNA and induction of anti-nucleoprotein antibodies after SARS-CoV-2 challenge. In contrast, a single intranasal dose of ChAd-SARS-CoV-2-S induces high levels of neutralizing antibodies, promotes systemic and mucosal IgA and T cell responses, and virtually completely prevents SARS-CoV-2 infection in both the upper and lower respiratory tracts. Intranasal administration of ChAd-SARS-CoV-2-S is a candidate for preventing SARS-CoV-2 infection and transmission, and curtailing pandemic spread.
has issue date	2020-08-19(xsd:dateTime)
bibo:doi	10.1016/j.cell.2020.08.026
has license	els-covid
sha1sum (hex)	6777a5a1cbe7f111257c0ce7a1f62f91e7faf34e
schema:url	https://doi.org/10.1016/j.cell.2020.08.026
resource representing a document's title	A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2
has PubMed Central identifier	PMC7437481
schema:publication	Cell
resource representing a document's body	covid:6777a5a1cbe7f111257c0ce7a1f62f91e7faf34e#body_text
is schema:about of	named entity 'Coronavirus' named entity 'transmission' named entity 'viral' named entity 'vectored' named entity 'lung infection' named entity 'https' named entity 'SARS-CoV-2' named entity 'vaccine' named entity 'SARS-CoV-2' named entity 'Disease' named entity 'adenovirus' named entity 'global health' named entity 'IgA' named entity 'protein' named entity 'SARS-CoV-2' named entity 'Coronavirus' named entity 'respiratory' named entity 'administration' named entity 'immunity' named entity 'angiotensin-converting enzyme 2' named entity 'infection' named entity 'upper' named entity 'respiratory' named entity 'upper' named entity 'vaccine'

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