About: Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes

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About: Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes
Creator	Li, Douyue Pan, Saichao Peng, Shan Tan, Zhongyang Zhang, Hongxi
Source	Elsevier; Medline; PMC
abstract	Abstract Microsatellites (SSRs) are ubiquitous in coding and non-coding regions of the Ebolavirus genomes. We synthetically analyzed the microsatellites in whole-genome and terminal regions of 219 Ebolavirus genomes from five species. The Ebolavirus sequences were observed with small intraspecies variations and large interspecific variations, especially in the terminal non-coding regions. Only five conserved microsatellites were detected in the complete genomes, and four of them which well base-paired to help forming conserved stem-loop structures mainly appeared in the terminal non-coding regions. These results suggest that the conserved microsatellites may be evolutionary selected to form conserved secondary structures in 5′, 3′ terminals of Ebolavirus genomes. It may help to understand the biological significance of microsatellites in Ebolavirus and also other virus genomes.
has issue date	2019-06-30(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2019.04.192
bibo:pmid	31078274
has license	els-covid
sha1sum (hex)	683a6f462c0061d3ffe7068fe7bd186049e3c884
schema:url	https://doi.org/10.1016/j.bbrc.2019.04.192
resource representing a document's title	Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes
has PubMed Central identifier	PMC7092875
has PubMed identifier	31078274
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:683a6f462c0061d3ffe7068fe7bd186049e3c884#body_text
is schema:about of	named entity 'CONTRIBUTE ' named entity 'non-coding regions' named entity 'structures' named entity 'sequences' named entity 'EBOLAVIRUS' named entity 'GENOME' named entity 'PAIRED' named entity 'EBOLAVIRUS' named entity 'UNDERSTAND' named entity 'THESE' named entity 'TO FORM' named entity 'MAY BE' named entity 'BIOLOGICAL' named entity 'CODING' named entity 'ANALYZED' named entity 'STEM-LOOP' named entity 'SEQUENCES' named entity 'CONSERVED' named entity 'VARIATIONS' named entity 'GENOMES' named entity 'CONSERVED' named entity 'TERMINAL' covid:arg/683a6f462c0061d3ffe7068fe7bd186049e3c884 named entity 'MICROSATELLITES' named entity 'TO HELP' named entity 'VIRUS' named entity 'STEM-LOOP' named entity '219' named entity 'SIGNIFICANCE' named entity 'RESULTS' named entity 'LARGE' named entity 'STRUCTURES' named entity 'SECONDARY' named entity 'UBIQUITOUS' named entity 'OBSERVED' named entity 'SPECIES' named entity 'SMALL' named entity 'GENOMES' named entity 'BASE' named entity 'COMPLETE' named entity 'HELP' named entity 'REGIONS' named entity 'DETECTED' named entity 'MICROSATELLITES' named entity 'FORMING' named entity 'SELECTED' named entity 'STRUCTURES' named entity 'NON-' named entity 'SUGGEST' named entity 'stem-loop' named entity 'observed' named entity 'complete' named entity 'The' named entity 'genomes' named entity 'terminals' named entity 'Microsatellites' named entity 'whole-genome' named entity 'base-paired' named entity 'secondary structures' named entity 'genomes' named entity 'Ebolavirus' named entity 'virus' named entity 'stem-loop structures' named entity 'genomes' named entity 'microsatellites' named entity 'synthetically' named entity 'microsatellites' named entity 'microsatellite' named entity 'virus' named entity 'genomes' named entity 'gene regulation' named entity 'sequence alignment' named entity 'Sequence analysis' named entity 'microsatellites' named entity 'Microsatellites' named entity 'genomes' named entity 'single point mutation'

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