About: Purifying Selection Can Obscure the Ancient Age of Viral Lineages

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Purifying Selection Can Obscure the Ancient Age of Viral Lineages
Creator	Wertheim, Joel Drummond, Alexei Kosakovsky, Sergei
Source	Medline; PMC
abstract	Statistical methods for molecular dating of viral origins have been used extensively to infer the time of most common recent ancestor for many rapidly evolving pathogens. However, there are a number of cases, in which epidemiological, historical, or genomic evidence suggests much older viral origins than those obtained via molecular dating. We demonstrate how pervasive purifying selection can mask the ancient origins of recently sampled pathogens, in part due to the inability of nucleotide-based substitution models to properly account for complex patterns of spatial and temporal variability in selective pressures. We use codon-based substitution models to infer the length of branches in viral phylogenies; these models produce estimates that are often considerably longer than those obtained with traditional nucleotide-based substitution models. Correcting the apparent underestimation of branch lengths suggests substantially older origins for measles, Ebola, and avian influenza viruses. This work helps to reconcile some of the inconsistencies between molecular dating and other types of evidence concerning the age of viral lineages.
has issue date	2011-06-24(xsd:dateTime)
bibo:doi	10.1093/molbev/msr170
bibo:pmid	21705379
has license	bronze-oa
sha1sum (hex)	6929c0cdf46c3ce1e9c963487cc83c986a2870ef
schema:url	https://doi.org/10.1093/molbev/msr170
resource representing a document's title	Purifying Selection Can Obscure the Ancient Age of Viral Lineages
has PubMed Central identifier	PMC3247791
has PubMed identifier	21705379
schema:publication	Molecular Biology and Evolution
resource representing a document's body	covid:6929c0cdf46c3ce1e9c963487cc83c986a2870ef#body_text
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