About: Up-Regulation of Mcl-1 and Bak by Coronavirus Infection of Human, Avian and Animal Cells Modulates Apoptosis and Viral Replication

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About: Up-Regulation of Mcl-1 and Bak by Coronavirus Infection of Human, Avian and Animal Cells Modulates Apoptosis and Viral Replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Up-Regulation of Mcl-1 and Bak by Coronavirus Infection of Human, Avian and Animal Cells Modulates Apoptosis and Viral Replication
Creator	Liao, Y Liu, D Tam, J Zhong, Y Fang, S
source	Medline; PMC
abstract	Virus-induced apoptosis and viral mechanisms that regulate this cell death program are key issues in understanding virus-host interactions and viral pathogenesis. Like many other human and animal viruses, coronavirus infection of mammalian cells induces apoptosis. In this study, the global gene expression profiles are first determined in IBV-infected Vero cells at 24 hours post-infection by Affymetrix array, using avian coronavirus infectious bronchitis virus (IBV) as a model system. It reveals an up-regulation at the transcriptional level of both pro-apoptotic Bak and pro-survival myeloid cell leukemia-1 (Mcl-1). These results were further confirmed both in vivo and in vitro, in IBV-infected embryonated chicken eggs, chicken fibroblast cells and mammalian cells at transcriptional and translational levels, respectively. Interestingly, the onset of apoptosis occurred earlier in IBV-infected mammalian cells silenced with short interfering RNA targeting Mcl-1 (siMcl-1), and was delayed in cells silenced with siBak. IBV progeny production and release were increased in infected Mcl-1 knockdown cells compared to similarly infected control cells, while the contrary was observed in infected Bak knockdown cells. Furthermore, IBV infection-induced up-regulation of GADD153 regulated the expression of Mcl-1. Inhibition of the mitogen-activated protein/extracellular signal-regulated kinase (MEK/ERK) and phosphoinositide 3-kinase (PI3K/Akt) signaling pathways by chemical inhibitors and knockdown of GADD153 by siRNA demonstrated the involvement of ER-stress response in regulation of IBV-induced Mcl-1 expression. These results illustrate the sophisticated regulatory strategies evolved by a coronavirus to modulate both virus-induced apoptosis and viral replication during its replication cycle.
has issue date	2012-01-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0030191
bibo:pmid	22253918
has license	cc-by
sha1sum (hex)	693d0f533004851d03a1f38a336f6aa943ea2733
schema:url	https://doi.org/10.1371/journal.pone.0030191
resource representing a document's title	Up-Regulation of Mcl-1 and Bak by Coronavirus Infection of Human, Avian and Animal Cells Modulates Apoptosis and Viral Replication
has PubMed Central identifier	PMC3256233
has PubMed identifier	22253918
schema:publication	PLoS One
resource representing a document's body	covid:693d0f533004851d03a1f38a336f6aa943ea2733#body_text
is schema:about of	named entity 'VIRAL REPLICATION' named entity 'progeny' named entity 'regulation' named entity 'fibroblast' named entity 'replication cycle' named entity 'cell' named entity 'induces' named entity 'virus' named entity 'expression' named entity 'key' named entity 'IBV' named entity 'sophisticated' named entity 'ERK' named entity 'up-regulation' named entity 'level' named entity 'Infection' named entity 'Avian' named entity 'HUMAN' named entity 'MCL-1' named entity 'INFECTED' named entity 'GLOBAL' named entity 'IBV' named entity 'TRANSCRIPTIONAL' named entity 'POST' named entity 'MODULATE' named entity 'REGULATE' named entity 'CHICKEN' named entity 'ITS' named entity 'MAMMALIAN' named entity 'APOPTOSIS' named entity 'INVOLVEMENT' named entity 'REPLICATION CYCLE' named entity 'IN VITRO' named entity '24 HOURS' named entity 'MYELOID CELL' named entity 'CONFIRMED' named entity 'DELAYED' named entity 'TARGETING' named entity 'LEVEL' named entity 'ISSUES' named entity 'EVOLVED' named entity 'LIKE' named entity 'PROTEIN' named entity 'PRODUCTION' named entity 'EXPRESSION' named entity 'OCCURRED' named entity 'GENE EXPRESSION PROFILES' named entity 'REGULATED' named entity 'INTERACTIONS' named entity 'APOPTOTIC' named entity 'THESE' named entity 'STRESS RESPONSE' named entity 'KINASE' named entity 'EARLIER' named entity 'RESULTS' named entity 'INHIBITION' named entity 'AVIAN CORONAVIRUS' named entity 'LEVELS' named entity 'UNDERSTANDING' named entity 'HUMAN' named entity 'IN VIVO' named entity 'CONTROL' named entity 'SIGNAL' named entity 'REVEALS' named entity 'PRO-SURVIVAL' covid:arg/693d0f533004851d03a1f38a336f6aa943ea2733 named entity 'GADD153' named entity 'INHIBITORS' named entity 'STRATEGIES' named entity 'APOPTOSIS' named entity 'VIRUS' named entity 'CORONAVIRUS INFECTION' named entity 'MCL-1' named entity 'ANIMAL CELLS' named entity 'UP-REGULATION' named entity 'VIRAL' named entity 'INFECTION'

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