About: Clinical, pathological, and molecular investigation of Mycoplasma pulmonis-induced murine respiratory mycoplasmosis in a rat (Rattus norvegicus) colony

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About: Clinical, pathological, and molecular investigation of Mycoplasma pulmonis-induced murine respiratory mycoplasmosis in a rat (Rattus norvegicus) colony Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical, pathological, and molecular investigation of Mycoplasma pulmonis-induced murine respiratory mycoplasmosis in a rat (Rattus norvegicus) colony
Creator	Chawla, Saurabh Jena, Sarita Mahara, Kuna Sahu, Nilanjan Venkatsan, Balaji
Source	Medline; PMC
abstract	AIM: Mycoplasma pulmonis (MP) remains potentially important rodent pathogen causing murine respiratory mycoplasmosis (MRM) which may go undiagnosed due to its asymptomatic nature. In the present study, we carried out clinical, pathological, and molecular investigations of MP-induced MRM in a rat colony. MATERIALS AND METHODS: Two female Wistar rats were observed to be diseased in animal facility of NISER, Bhubaneswar, and were kept in isolation for further investigation. Both the animals were found to be positive for MP after serological and molecular tests. Thereafter, whole rat colony comprising of 36 animals was segregated based on clinical symptoms and further sampled for histopathological, serological, and molecular investigations. Tracheal washing and infected lung tissue were collected during necropsy examination for DNA extraction. Molecular diagnosis was done by polymerase chain reaction (PCR) assay using species-specific primers. RESULT:: Classical symptoms of MP-associated respiratory tract infection were observed in only 2 of 36 infected animals, and most of the animals were found asymptomatic to the disease; however, all the animals were found to be carrier after necropsy and PCR assay. Gross and histopathological finding suggested severe congestion of the lungs along with suppurative and necrotizing pneumonia. The disease is confirmed by molecular diagnosis using species-specific primers in PCR assay. CONCLUSION: MRM may go undiagnosed due to asymptomatic nature. Detailed study of clinical symptoms, pathology, serology, and PCR-based molecular approach may aid in health monitoring and detection of MRM in a rodent colony reared for experimental purpose.
has issue date	2017-11-25(xsd:dateTime)
bibo:doi	10.14202/vetworld.2017.1378-1382
bibo:pmid	29263602
has license	cc-by
sha1sum (hex)	69e7ecb2ece358ef53df31c8ba497a183b007cc1
schema:url	https://doi.org/10.14202/vetworld.2017.1378-1382
resource representing a document's title	Clinical, pathological, and molecular investigation of Mycoplasma pulmonis-induced murine respiratory mycoplasmosis in a rat (Rattus norvegicus) colony
has PubMed Central identifier	PMC5732346
has PubMed identifier	29263602
schema:publication	Vet World
resource representing a document's body	covid:69e7ecb2ece358ef53df31c8ba497a183b007cc1#body_text
is schema:about of	named entity 'CLINICAL' named entity 'causing' named entity 'nature' named entity 'pathogen' named entity 'murine' named entity 'INDUCED' named entity 'CARRIED' named entity 'IMPORTANT' named entity 'INDUCED' named entity 'MYCOPLASMA PULMONIS' named entity 'RAT' named entity 'PATHOGEN' named entity 'ASYMPTOMATIC' named entity 'COLONY' named entity 'PATHOLOGICAL' named entity 'CLINICAL' named entity 'MOLECULAR' named entity 'STUDY' named entity 'MRM' named entity 'AIM' named entity 'RODENT' named entity 'UNDIAGNOSED' named entity 'NATURE' named entity 'ITS' named entity 'CAUSING' named entity 'PRESENT' named entity 'PATHOLOGICAL' named entity 'MOLECULAR' named entity 'MYCOPLASMA PULMONIS' named entity 'RAT' named entity 'COLONY' named entity 'INVESTIGATION' named entity 'DUE TO' named entity 'MURINE RESPIRATORY MYCOPLASMOSIS' named entity 'MURINE RESPIRATORY MYCOPLASMOSIS' named entity 'INVESTIGATIONS' covid:arg/69e7ecb2ece358ef53df31c8ba497a183b007cc1 named entity 'rodent' named entity 'postmortem examination' named entity 'sneezing' named entity 'tissue sample' named entity 'assay' named entity '3, 4' named entity 'American Veterinary Medical Association' named entity 'veterinarian' named entity '8.2' named entity 'microorganism' named entity 'ethidium bromide' named entity 'subclinical' named entity '2a-c' named entity 'inflammatory cells' named entity 'euthanasia' named entity 'Theiler's murine encephalomyelitis virus' named entity 'PCR' named entity 'Lung tissue' named entity 'inhalation' named entity 'rodent' named entity 'Necropsy' named entity 'paraffin wax' named entity 'PCR' named entity 'uterine' named entity 'lungs' named entity 'rales' named entity 'septum' named entity 'rodent' named entity 'carbon dioxide' named entity 'trachea' named entity 'respiratory tract' named entity 'histological' named entity 'lung' named entity 'PCR reaction' named entity 'inflammatory cells' named entity 'trachea' named entity 'pathological' named entity 'murine' named entity 'Mycoplasma pulmonis' named entity 'murine'

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