About: Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study
Creator	Leruez-Ville, Marianne Thumerelle, Caroline Delacourt, Christophe Le Bourgeois, Muriel Varon, Emmanuelle Brosco, Jeffrey Es Ferroni, Agn Fayon, Michael Lainie, Friedman Ois Br Emont, Franç Paul, Diane Ross,
Source	Elsevier; Medline; PMC
abstract	Objective To investigate the risk factors of empyema after acute viral infection and to clarify the hypothesized association(s) between empyema and some viruses and/or the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Study design A case-control study was conducted in 15 centers. Cases and controls were enrolled for a source population of children 3-15 years of age with acute viral infections between 2006 and 2009. Results Among 215 empyemas, 83 cases (children with empyema and acute viral infection within the 15 preceding days) were included, and 83 controls (children with acute viral infection) were matched to cases. Considering the intake of any drug within 72 hours after acute viral infection onset and at least 6 consecutive days of antibiotic use and at least 1 day of NSAIDs exposure, the multivariable analysis retained an increased risk of empyema associated with NSAIDs exposure (aOR 2.79, 95% CI 1.4-5.58, P = .004), and a decreased risk associated with antibiotic use (aOR 0.32, 95% CI 0.11-0.97, P = .04). The risk of empyema associated with NSAIDs exposure was greater for children not prescribed an antibiotic and antibiotic intake diminished that risk for children given NSAIDs. Conclusions NSAIDs use during acute viral infection is associated with an increased risk of empyema in children, and antibiotics are associated with a decreased risk. The presence of antibiotic-NSAIDs interaction with this risk is suggested. These findings suggest that NSAIDs should not be recommended as a first-line antipyretic treatment during acute viral infections in children.
has issue date	2016-08-31(xsd:dateTime)
bibo:doi	10.1016/j.jpeds.2016.05.025
bibo:pmid	27339249
has license	els-covid
sha1sum (hex)	69eb6f3994e9038a39895bc685be0d3aac1c2746
schema:url	https://doi.org/10.1016/j.jpeds.2016.05.025
resource representing a document's title	Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study
has PubMed Central identifier	PMC7094675
has PubMed identifier	27339249
schema:publication	The Journal of Pediatrics
resource representing a document's body	covid:69eb6f3994e9038a39895bc685be0d3aac1c2746#body_text
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