About: Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

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About: Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
Creator	Andrabi, Raiees Song, Ge Burton, Dennis He, Wan-Ting Teijaro, John Wilson, Ian Wu, Nicholas Ricciardi, Michael Smith, Davey Yuan, Meng Ramirez, Sydney Nemazee, David Rogers, Thomas Abbott, Robert Beutler, Nathan Briney, Bryan Burns, Alison Callaghan, Sean Garcia, Elijah Huang, Deli Hurtado, Jonathan Jardine, Joseph Landais, Elise Limbo, Oliver Parren, Mara Peng, Linghang Rawlings, Stephen Ricketts, James Smith, Chloe Sok, Devin Voss, James Woehl, Jordan Yang, Linlin Zhao, Fangzhu
source	Medline; PMC
abstract	Countermeasures to prevent and treat COVID-19 are a global health priority. We enrolled a cohort of SARS-CoV-2-recovered participants, developed neutralization assays to interrogate antibody responses, adapted our high-throughput antibody generation pipeline to rapidly screen over 1800 antibodies, and established an animal model to test protection. We isolated potent neutralizing antibodies (nAbs) to two epitopes on the receptor binding domain (RBD) and to distinct non-RBD epitopes on the spike (S) protein. We showed that passive transfer of a nAb provides protection against disease in high-dose SARS-CoV-2 challenge in Syrian hamsters, as revealed by maintained weight and low lung viral titers in treated animals. The study suggests a role for nAbs in prophylaxis, and potentially therapy, of COVID-19. The nAbs define protective epitopes to guide vaccine design.
has issue date	2020-06-15(xsd:dateTime)
bibo:doi	10.1126/science.abc7520
bibo:pmid	32540903
has license	cc-by
sha1sum (hex)	69f56a1d85efab9227c3360847205c05405cfbe1
schema:url	https://doi.org/10.1126/science.abc7520
resource representing a document's title	Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
has PubMed Central identifier	PMC7299280
has PubMed identifier	32540903
schema:publication	Science
resource representing a document's body	covid:69f56a1d85efab9227c3360847205c05405cfbe1#body_text
is schema:about of	named entity 'animal model' named entity 'neutralizing antibodies' named entity 'RBD' named entity 'control group' named entity 'SARS-CoV-2' named entity 'protein' named entity 'Simpson's rule' named entity 'SARS-CoV-1' named entity 'recombinant' named entity 'infection' named entity 'virus' named entity 'SARS-CoV-2' named entity 'Convalescent serum' named entity 'antibody dependent enhancement' named entity 'plasma' named entity 'weight loss' named entity 'viral load' named entity 'epitope' named entity 'viral infection' named entity 'vaccine design' named entity 'RBD' named entity 'neutralizing antibody' named entity 'protein' named entity 'antibody' named entity 'potency' named entity 'SARS-CoV-2' named entity 'WA-1' named entity 'plasma' named entity 'antigens' named entity 'vaccine' named entity 'SARS-CoV-2' named entity 'PSV' named entity 'light chain' named entity 'ADE' named entity 'coronavirus infection' named entity 'epitope' named entity 'weight loss' named entity 'neutralizing antibodies' named entity 'pseudovirus' named entity 'causative agent' named entity 'serum concentrations' named entity 'mutation' named entity 'memory B cells' named entity 'Syrian hamster' named entity 'area-under-the-curve' named entity 'epitope' named entity 'ACE2' named entity 'SARS-CoV-2'

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