About: Ultrafiltration attenuates cardiopulmonary bypass–induced acute lung injury in a canine model of single-lung transplantation

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About: Ultrafiltration attenuates cardiopulmonary bypass–induced acute lung injury in a canine model of single-lung transplantation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ultrafiltration attenuates cardiopulmonary bypass–induced acute lung injury in a canine model of single-lung transplantation
Creator	Aoki, Tadashi Haga, Manabu Hayashi, Jun-Ichi Koike, Terumoto Saitoh, Masayuki Satoh, Koichi Toyabe, Shin-Ichi Tsuchida, Masanori
Source	Elsevier; Medline; PMC
abstract	Objective The purpose of this study was to investigate the effects of cardiopulmonary bypass and ultrafiltration on graft function in a canine single-lung transplantation model. Methods Fifteen left single-lung transplantations were done in weight-mismatched canine pairs. The animals were divided into 3 groups: group 1, in which transplantation was done without cardiopulmonary bypass; group 2, in which transplantation was done with cardiopulmonary bypass and in which the cardiopulmonary bypass flow was decreased slowly with controlled pulmonary artery pressure; and group 3, in which transplantation was done with cardiopulmonary bypass and ultrafiltration. Hemodynamic parameters and lung function were monitored for 6 hours after reperfusion. The grafts were harvested for histologic studies, myeloperoxidase assay, and real-time quantitive reverse transcription–polymerase chain reaction of mRNA encoding interleukin 6. Results The hemodynamic parameters were similar among the 3 groups. In group 1 Pao 2 and alveolar to arterial gradient for O2 levels were excellent throughout the 6-hour observation period, but in group 2 they progressively deteriorated. However, ultrafiltration significantly (P = .02) improved the Pao 2 level in group 3. On histology, interstitial edema and polynuclear cell infiltration were most marked in group 2 and significantly worse than in groups 1 and 3. Myeloperoxidase assay and real-time quantitative reverse transcription–polymerase chain reaction showed increased myeloperoxidase activity and interleukin 6 gene expression in group 2 grafts compared with group 1 grafts. Myeloperoxidase activity and interleukin 6 gene expression were suppressed with ultrafiltration. Conclusions Cardiopulmonary bypass had negative effects on the graft, but ultrafiltration attenuated acute lung dysfunction by reducing the inflammatory response.
has issue date	2006-12-31(xsd:dateTime)
bibo:doi	10.1016/j.jtcvs.2006.08.020
bibo:pmid	17140974
has license	els-covid
sha1sum (hex)	6a09678dcc66bd682efd73b5587e18189dc8e946
schema:url	https://doi.org/10.1016/j.jtcvs.2006.08.020
resource representing a document's title	Ultrafiltration attenuates cardiopulmonary bypass–induced acute lung injury in a canine model of single-lung transplantation
has PubMed Central identifier	PMC7127439
has PubMed identifier	17140974
schema:publication	The Journal of Thoracic and Cardiovascular Surgery
resource representing a document's body	covid:6a09678dcc66bd682efd73b5587e18189dc8e946#body_text
is schema:about of	named entity 'JOURNAL ' named entity 'CARDIOPULMONARY BYPASS' named entity 'LUNG TRANSPLANTATION' named entity 'TO INVESTIGATE' covid:arg/6a09678dcc66bd682efd73b5587e18189dc8e946 named entity '80%' named entity 'GRAFT FUNCTION' named entity 'STUDY' named entity 'OBJECTIVE' named entity 'THORACIC AND CARDIOVASCULAR SURGERY' named entity 'CANINE' named entity 'NUMBER' named entity 'PURPOSE' named entity 'SINGLE' named entity 'CARDIOTHORACIC TRANSPLANTATION' named entity 'EFFECTS' named entity 'ULTRAFILTRATION' named entity 'MODEL' named entity 'Transplantation' named entity 'cardiopulmonary bypass' named entity 'canine' named entity 'E-selectin' named entity 'reperfusion' named entity 'flushing' named entity 'pulmonary artery' named entity 'adverse effects' named entity 'left main bronchus' named entity 'thiopental sodium' named entity 'pulmonary pressure' named entity 'Positive end-expiratory pressure' named entity 'IL-6' named entity 'cytokine' named entity 'femoral artery' named entity 'activated clotting time' named entity 'tidal volume' named entity 'oxygenator' named entity 'purse-string suture' named entity 'pulmonary injury' named entity 'inflammatory response' named entity 'perivascular' named entity 'Intravenous' named entity 'IL-6' named entity 'lung transplantation' named entity 'arterial blood gas' named entity 'heat exchanger' named entity 'lungs' named entity 'lung transplantation' named entity 'lungs' named entity 'clinical studies' named entity 'adhesion molecules' named entity 'venous cannula' named entity 'roller pump' named entity 'left lung' named entity 'pulmonary artery' named entity 'hematoxylin and eosin' named entity 'positive end-expiratory pressure' named entity 'anesthetized' named entity 'pancuronium bromide' named entity 'lungs' named entity 'canine' named entity 'lung transplantation' named entity 'pulmonary artery pressure' named entity 'laboratory animals' named entity 'dextrose' named entity 'treatment groups' named entity 'canine' named entity 'left atrial' named entity 'lung injury' named entity '1.2' named entity 'bronchus' named entity 'lung transplant' named entity 'contralateral' named entity 'oxygen' named entity 'blood transfusion'

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