About: Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease

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About: Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease
Creator	Aldasoro, Constanza Aldasoro, Martin Cauli, Omar Guerra-Ojeda, Sol Iradi, Antonio Jorda, Adrián Marchio, Patricia Obrador, Elena M A Vila, Jose Mauricio, Dolores Santonja, Jose Valles, Soraya
Source	PMC
abstract	The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes. IL-3 is involved in inflammation and ABDF1 intervenes normally in the transport across cell membranes and both were found up-regulated in APP/PS1 mice compared to Wild type mice. Furthermore, CCR5 expression was decreased and both CCL3 and CCL4 chemokines were highly expressed indicating a possible gliosis and probably an increase in chemotaxis from lymphocytes and T cell generation. We also noted for the first time, a CCR8 increase expression with diminution of its CCL1 chemokine, both normally involved in protection from bacterial infection and demyelination. Control of inflammatory proteins will be the next step in understanding the progression of AD and also in determining the mechanisms that can develop in this disease.
has issue date	2019-01-01(xsd:dateTime)
bibo:doi	10.7150/ijbs.26703
bibo:pmid	30745834
has license	cc-by-nc
sha1sum (hex)	6a14ff1798aa6ca90d45bab127740593ab37fac3
schema:url	https://doi.org/10.7150/ijbs.26703
resource representing a document's title	Changes in Chemokines and Chemokine Receptors Expression in a Mouse Model of Alzheimer's Disease
has PubMed Central identifier	PMC6367555
has PubMed identifier	30745834
schema:publication	Int J Biol Sci
resource representing a document's body	covid:6a14ff1798aa6ca90d45bab127740593ab37fac3#body_text
is schema:about of	named entity 'IL-3' named entity 'inflammatory' named entity 'gliosis' named entity 'transport' named entity 'PS1' named entity 'studies' named entity 'DISEASE' named entity 'MODEL OF' named entity 'CHEMOKINES' named entity 'EXPRESSION' named entity 'CHEMOKINE RECEPTORS' named entity 'NOTED' named entity 'DIMINUTION' named entity 'PROTECTION' named entity 'TRANSPORT' named entity 'COMPARING' named entity 'ITS' named entity 'PROTEIN ' named entity 'PRESENILIN-1' named entity 'CCR8' named entity 'GLIOSIS' named entity 'WILD TYPE' named entity 'SIGNIFICANT' named entity 'QUANTITATIVE RT-PCR' named entity 'IL-3' named entity '27S' named entity 'AMYLOID PRECURSOR PROTEIN' named entity 'PROGRESSION' named entity 'USED' named entity 'PROTEINS' named entity 'WESTERN' named entity 'FREQUENTLY' named entity 'FINDINGS' named entity 'APP' named entity 'A MOUSE' named entity 'CHANGES' named entity '27S' named entity 'ALZHEIMER' named entity 'MOUSE MODEL' named entity 'RELEVANT' named entity 'DATA' named entity 'DEMYELINATION' named entity 'CCL4' named entity 'INVOLVED' named entity 'DECREASED' named entity 'LYMPHOCYTES' named entity 'UNDERSTANDING' named entity 'ELEVATION' named entity 'CONTROL' named entity 'BEHAVIORAL' named entity 'HIGHLY' named entity 'CHEMOKINES' named entity 'EXPRESSED' named entity 'STUDIES' named entity 'MODEL' named entity 'INFLAMMATORY' named entity 'ASSOCIATED WITH' named entity 'BACTERIAL INFECTION' named entity 'INDICATING' named entity 'DETERMINED BY' named entity 'INCREASED' named entity 'MECHANISM' named entity 'USING' named entity 'COMPARED' named entity 'MOUSE MODEL' named entity 'TIME' named entity 'MICE' named entity 'POSSIBLE' named entity 'PROBABLY' named entity 'EXPRESSION'

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