About: Etiologies and outcome of acute respiratory failure in HIV-infected patients

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Etiologies and outcome of acute respiratory failure in HIV-infected patients
Creator	Molina, Jean-Michel Darmon, Michael Schlemmer, Benoît Mayaux, Julien Pavie, Juliette Azoulay, Á Barbier, F Coquet, Á Darmon, Á Legriel, Á Lie Azoulay, É Mayaux, Á Molina, J.-M Pavie, Á Schlemmer, Á
source	PMC
abstract	OBJECTIVE: To assess the etiologies and outcome of acute respiratory failure (ARF) in HIV-infected patients over the first decade of combination antiretroviral therapy (ART) use. METHODS: Retrospective study of all HIV-infected patients (n = 147) admitted to a single intensive care unit (ICU) for ARF between 1996 and 2006. RESULTS: ARF revealed the diagnosis of HIV infection in 43 (29.2%) patients. Causes of ARF were bacterial pneumonia (n = 74), Pneumocystis jirovecii pneumonia (PCP, n = 52), other opportunistic infections (n = 19), and noninfectious pulmonary disease (n = 33); the distribution of causes did not change over the 10-year study period. Two or more causes were identified in 33 patients. The 43 patients on ART more frequently had bacterial pneumonia and less frequently had opportunistic infections (P = 0.02). Noninvasive ventilation was needed in 49 patients and endotracheal intubation in 42. Hospital mortality was 19.7%. Factors independently associated with mortality were mechanical ventilation [odds ratio (OR) = 8.48, P < 0.0001], vasopressor use (OR, 4.48; P = 0.03), time from hospital admission to ICU admission (OR, 1.05 per day; P = 0.01), and number of causes (OR, 3.19; P = 0.02). HIV-related variables (CD4 count, viral load, and ART) were not associated with mortality. CONCLUSION: Bacterial pneumonia and PCP remain the leading causes of ARF in HIV-infected patients in the ART era. Hospital survival has improved, and depends on the extent of organ dysfunction rather than on HIV-related characteristics.
has issue date	2009-07-03(xsd:dateTime)
bibo:doi	10.1007/s00134-009-1559-4
bibo:pmid	19575179
has license	no-cc
sha1sum (hex)	6a9f85e4f1575fe852d130b388a2d8e03e0f2e82
schema:url	https://doi.org/10.1007/s00134-009-1559-4
resource representing a document's title	Etiologies and outcome of acute respiratory failure in HIV-infected patients
has PubMed Central identifier	PMC7094937
has PubMed identifier	19575179
schema:publication	Intensive Care Med
resource representing a document's body	covid:6a9f85e4f1575fe852d130b388a2d8e03e0f2e82#body_text
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