About: In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis

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About: In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis
Creator	Crokaert, Françoise De Schutter, Iris De Waele, Marc Dreesman, Alexandra Malfroot, Anne Piérard, Denis Soetens, Oriane Verhaegen, Jan
Source	Medline; PMC
abstract	BACKGROUND: Young children with persistent wheezing pose a diagnostic and therapeutical challenge to the pediatrician. We aimed to evaluate bacterial bronchial infection as a possible reason for non response to conventional asthma therapy, and to identify and characterise the predominant pathogens involved. METHODS: We retrospectively analysed microbiological and cytological findings in a selected population of young wheezers with symptoms unresponsive to inhaled corticosteroid (ICS) therapy, who underwent flexible bronchoscopy with bronchoalveolar lavage (BAL). Procedural measures were taken to limit contamination risk and quantitative bacterial culture of BAL fluid (significance cut-off ≥ 10(4) colony-forming units/ml) was used. Modern microbiological methods were used for detection of a wide panel of pathogens and for characterisation of the bacterial isolates. RESULTS: 33 children aged between 4 and 38 months, without structural anomalies of the conductive airways were evaluated. Significant bacterial BAL cultures were found in 48,5 % of patients. Haemophilus influenzae was isolated in 30,3 %, Streptococcus pneumoniae in 12,1 % and Moraxella catarrhalis in 12,1 %. All H. influenzae isolates were non-encapsulated strains and definitely distinguished from non-haemolytic H. haemolyticus. Respiratory viruses were detected in 21,9 % of cases with mixed bacterial-viral infection in 12,1 %. Cytology revealed a marked neutrophilic inflammation. CONCLUSIONS: Bacterial infection of the bronchial tree is common in persistent preschool wheezers and provides a possible explanation for non response to ICS therapy. Non-typeable H. influenzae seems to be the predominant pathogen involved, followed by S. pneumoniae and M. catarrhalis.
has issue date	2012-06-22(xsd:dateTime)
bibo:doi	10.1186/1471-2431-12-83
bibo:pmid	22726254
has license	cc-by
sha1sum (hex)	6ab7d80bb6dc14cac7fe9c7d5a6060af434bef0a
schema:url	https://doi.org/10.1186/1471-2431-12-83
resource representing a document's title	In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis
has PubMed Central identifier	PMC3420249
has PubMed identifier	22726254
schema:publication	BMC Pediatr
resource representing a document's body	covid:6ab7d80bb6dc14cac7fe9c7d5a6060af434bef0a#body_text
is schema:about of	named entity 'evaluate' named entity 'involved' named entity 'POSE' named entity 'BACKGROUND' named entity 'YOUNG CHILDREN' named entity 'PERSISTENT' named entity 'DIAGNOSTIC' named entity 'BACTERIAL' covid:arg/6ab7d80bb6dc14cac7fe9c7d5a6060af434bef0a named entity 'POSSIBLE' named entity 'WHEEZING' named entity 'BRONCHIAL INFECTION' named entity 'RESPONSE TO' named entity 'NON' named entity 'ASTHMA' named entity 'PREDOMINANT' named entity 'REASON FOR' named entity 'PEDIATRICIAN' named entity 'CONVENTIONAL' named entity 'EVALUATE' named entity 'CHALLENGE' named entity 'PATHOGENS' named entity 'TO IDENTIFY' named entity 'THERAPY' named entity 'INVOLVED' named entity 'bacterial' named entity 'antibiotic therapy' named entity 'NTHi' named entity 'infection' named entity 'genetic disorders' named entity 'young children' named entity 'β-lactamase' named entity 'GERD' named entity 'pediatric' named entity 'bacterial culture' named entity 'cytological' named entity 'inflammation' named entity 'treatment adherence' named entity 'mannitol salt agar' named entity 'Serratia marcescens' named entity 'reflux' named entity 'bronchial infection' named entity 'human body' named entity 'bacterial infection' named entity 'pediatrician' named entity 'amoxicillin' named entity 'antibiotic treatment' named entity 'comorbidities' named entity 'viruses' named entity 'H. influenzae' named entity 'bronchial infection' named entity 'pathogen' named entity 'H. influenzae' named entity 'wheezing' named entity 'young children' named entity 'Multiple comparisons' named entity 'biofilm formation' named entity 'coronaviruses' named entity 'pediatric' named entity 'nucleated cells' named entity 'microbiological evaluation' named entity 'bronchial inflammation' named entity 'Cytocentrifuge' named entity 'Glasgow' named entity 'bacterial cultures' named entity 'cough' named entity 'aerobic' named entity 'immune deficiency' named entity 'bronchoscopy' named entity 'inflammatory' named entity 'allergic' named entity 'infection' named entity 'young children' named entity 'in-vitro'

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