About: Attaching clinical significance to COVID-19-associated diarrhea

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Attaching clinical significance to COVID-19-associated diarrhea
Creator	Sun, Xiaodong Wang, Fantao Zheng, Chengbin Zheng, Shiliang
source	Elsevier; Medline; PMC
abstract	The Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), erupted in 2020 and created severe public health and socioeconomic challenges worldwide. A subset of patients, in addition to presenting with typical features such as fever, cough and dyspnea, was also afflicted with diarrhea. However, the clinical features and prognoses related to COVID-19-associated diarrhea have not attracted sufficient attention. This review of the medical literature examines the incidence, pathogenesis, clinical characteristics, fecal virus changes, prognoses and influencing factors of COVID-19-associated diarrhea. The reported incidence of diarrhea in patients with COVID-19 ranged from 2% to 49.5%. The main cause of diarrhea was found to be invasive by SARS-CoV-2 of ACE-2-expressing epithelial cells of the small intestine, causing local intestinal damage. This cellular invasion may be the key factor for the much longer duration of SARS-CoV-2 positivity observed for feces compared to pharyngeal swabs. The associated diarrhea in these patients upsets the balance of intestinal flora, resulting in more-severe disease intensity and worse prognosis. Clinicians should be vigilant to this kind of COVID-19-associated diarrhea, and design more effective prevention and treatment options for patients with positive fecal nucleic acid tests and intestinal microflora disorders.
has issue date	2020-11-01(xsd:dateTime)
bibo:doi	10.1016/j.lfs.2020.118312
bibo:pmid	32846165
has license	no-cc
sha1sum (hex)	6b7ab2dda16cc31c91d1d115f7ce14b7570c6624
schema:url	https://doi.org/10.1016/j.lfs.2020.118312
resource representing a document's title	Attaching clinical significance to COVID-19-associated diarrhea
has PubMed Central identifier	PMC7443214
has PubMed identifier	32846165
schema:publication	Life Sci
resource representing a document's body	covid:6b7ab2dda16cc31c91d1d115f7ce14b7570c6624#body_text
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