About: Identification of diverse full-length endogenous betaretroviruses in megabats and microbats

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About: Identification of diverse full-length endogenous betaretroviruses in megabats and microbats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Identification of diverse full-length endogenous betaretroviruses in megabats and microbats
Creator	Wang, Lin-Fa Cui, Jie Field, Hume Tachedjian, Mary Tachedjian, Gilda Holmes, Edward Hayward, Joshua
source	Medline; PMC
abstract	BACKGROUND: Betaretroviruses infect a wide range of species including primates, rodents, ruminants, and marsupials. They exist in both endogenous and exogenous forms and are implicated in animal diseases such as lung cancer in sheep, and in human disease, with members of the human endogenous retrovirus-K (HERV-K) group of endogenous betaretroviruses (βERVs) associated with human cancers and autoimmune diseases. To improve our understanding of betaretroviruses in an evolutionarily distinct host species, we characterized βERVs present in the genomes and transcriptomes of mega- and microbats, which are an important reservoir of emerging viruses. RESULTS: A diverse range of full-length βERVs were discovered in mega- and microbat genomes and transcriptomes including the first identified intact endogenous retrovirus in a bat. Our analysis revealed that the genus Betaretrovirus can be divided into eight distinct sub-groups with evidence of cross-species transmission. Betaretroviruses are revealed to be a complex retrovirus group, within which one sub-group has evolved from complex to simple genomic organization through the acquisition of an env gene from the genus Gammaretrovirus. Molecular dating suggests that bats have contended with betaretroviral infections for over 30 million years. CONCLUSIONS: Our study reveals that a diverse range of betaretroviruses have circulated in bats for most of their evolutionary history, and cluster with extant betaretroviruses of divergent mammalian lineages suggesting that their distribution may be largely unrestricted by host species barriers. The presence of βERVs with the ability to transcribe active viral elements in a major animal reservoir for viral pathogens has potential implications for public health.
has issue date	2013-03-27(xsd:dateTime)
bibo:doi	10.1186/1742-4690-10-35
bibo:pmid	23537098
has license	cc-by
sha1sum (hex)	6b810552f81fc62a9f69f64033011fd5c627c8ea
schema:url	https://doi.org/10.1186/1742-4690-10-35
resource representing a document's title	Identification of diverse full-length endogenous betaretroviruses in megabats and microbats
has PubMed Central identifier	PMC3621094
has PubMed identifier	23537098
schema:publication	Retrovirology
resource representing a document's body	covid:6b810552f81fc62a9f69f64033011fd5c627c8ea#body_text
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