About: Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity

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About: Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity
Creator	Foster, D Rao, Z Kannan, S Pang, H Wu, M
source	PMC
abstract	It is unknown whether base excision DNA repair (BER) proteins interact with mitogen-activated protein kinases (MAPK) under oxidation. Here, we explored roles of BER proteins in signaling transduction involving MAPK during hyperoxia. We demonstrated that ERK1/2 phosphorylation in A549 cells was increased in 95% O(2). p38 activity in A549 cells was also increased by exposure to 95% O(2). To evaluate regulatory roles of MAPK, we have transduced A549 cells and primary alveolar epithelial type II cells (AECII) to overexpress 8-oxoguanine DNA glycosylase (hOgg1). Overexpression of hOgg1 reduced hyperoxic toxicity in A549 and AECII cells. Furthermore, protection by BER against hyperoxia appeared to involve an upregulation of ERK1/2 and downregulation of p38. These observations demonstrate, for the first time, that reduction of hyperoxic toxicity by BER proteins may be involved with MAPK activity, thereby impacting cell survival. Furthermore, our studies suggest that modulation of MAPK may be used in combination with BER proteins to counteract hyperoxic toxicity.
has issue date	2005-07-29(xsd:dateTime)
bibo:doi	10.1038/sj.cdd.4401736
bibo:pmid	16052235
has license	no-cc
sha1sum (hex)	6dce083426abf61b739111de7118440075fce648
schema:url	https://doi.org/10.1038/sj.cdd.4401736
resource representing a document's title	Human 8-oxoguanine DNA glycosylase increases resistance to hyperoxic cytotoxicity in lung epithelial cells and involvement with altered MAPK activity
has PubMed Central identifier	PMC7091608
has PubMed identifier	16052235
schema:publication	Cell Death Differ
resource representing a document's body	covid:6dce083426abf61b739111de7118440075fce648#body_text
is schema:about of	named entity 'A549' named entity 'MAPK' named entity 'transduced' named entity 'toxicity' named entity 'toxicity' named entity 'cells' named entity 'demonstrated' named entity 'cell' named entity 'hyperoxic' named entity 'A549' named entity 'transduction' named entity 'These' named entity 'reduction' named entity 'MAPK' named entity 'cells' named entity 'cells' named entity 'p38' named entity 'DNA glycosylase' named entity 'A549' named entity 'A549' named entity 'hyperoxic' named entity 'MAPK' named entity 'overexpress' named entity 'toxicity' named entity 'MAPK' named entity '8-oxoguanine' named entity 'toxicity' named entity 'transduced' named entity 'mitogen-activated protein kinases' named entity 'p21' named entity 'epithelial type II cells' named entity 'dye' named entity 'mitosis' named entity 'MIS' named entity 'liposome' named entity 'p38' named entity 'transfection' named entity 'SP-C' named entity 'apoptosis' named entity 'primers' named entity 'toxicity' named entity 'post-transcriptional' named entity 'oxygen' named entity 'kinase' named entity 'toxicity' named entity 'MAPK' named entity 'lung' named entity 'DNA lesions' named entity 'Cell death' named entity 'Western blotting' named entity 'ERK1/2' named entity 'serum' named entity 'ERK1/2' named entity 'hyperoxia' named entity 'p53' named entity 'A549' named entity 'hyperoxia' named entity 'trypan blue' named entity 'p38 MAPK' named entity 'oxidant' named entity 'dye' named entity 'A549' named entity 'hyperoxia' named entity 'transfected' named entity 'downregulation' named entity 'phosphodiester backbone' named entity 'vector' named entity 'toxicity' named entity 'DNA glycosylase' named entity 'BER' named entity 'lung' named entity 'trypan blue' named entity 'hyperoxia' named entity 'propidium iodide' named entity 'hyperoxia' named entity 'nucleotide' named entity '8-oxo-dG'

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