About: Early days: genomics and human responses to infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early days: genomics and human responses to infection
Creator	Liu, Minghsun Popper, Stephen Relman, David Rubins, Kathleen
Source	Elsevier; Medline; PMC
abstract	DNA microarray-based gene transcript-profiling of the responses of primates to infection has begun to yield new insights into host–pathogen interactions; this approach, however, remains plagued by challenges and complexities that have yet to be adequately addressed. The rapidly changing nature over time of acute infectious diseases in a host, and the genetic diversity of microbial pathogens present unique problems for the design and interpretation of functional-genomic studies in this field. In addition, there are the more common problems related to heterogeneity within clinical samples, the complex, non-standardized confounding variables associated with human subjects and the complexities posed by the analysis and validation of highly parallel data. Whereas various approaches have been developed to address each of these issues, there are significant limitations that remain to be overcome. The resolution of these problems should lead to a better understanding of the dialogue between the host and pathogen.
has issue date	2006-05-06(xsd:dateTime)
bibo:doi	10.1016/j.mib.2006.04.006
bibo:pmid	16679048
has license	no-cc
sha1sum (hex)	6f147ad02e15472fb25d780a700a7594cf5ce269
schema:url	https://doi.org/10.1016/j.mib.2006.04.006
resource representing a document's title	Early days: genomics and human responses to infection
has PubMed Central identifier	PMC7108404
has PubMed identifier	16679048
schema:publication	Curr Opin Microbiol
resource representing a document's body	covid:6f147ad02e15472fb25d780a700a7594cf5ce269#body_text
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