About: Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells

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About: Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells
Creator	Chung, Young-Hwa Ahn, Jin-Hyun Cho, Il-Rae Lee, Im-Soon Min, Hye-Jin Oh, Sangtaek Park, Eun-Hee Srisuttee, Ratakorn Cho, Ho Johnston, Randal
Source	Elsevier; Medline; PMC
abstract	Abstract Many studies have shown that the activation of β-catenin signaling can promote oncogenesis, and it is therefore of interest to find agents that modulate this pathway. Recent work has shown using B lymphoma cells that infection by Epstein–Barr virus (EBV) and expression of its latent membrane protein (LMP)-1, cause increases in the expression of β-catenin and cellular transformation. Conversely, results from cell-based small molecule screening studies have shown that the antibiotic hexachlorophene can down-regulate β-catenin in colon cancer cells. Here we report that hexachlorophene also counteracts the elevated β-catenin levels in EBV-infected B lymphomas. This is associated with restoration in levels of Siah-1 (an E3 ubiquitin ligase that is active in β-catenin regulation) which had been diminished by LMP-1. Our results suggest that Siah-1 is targeted by both LMP-1 and hexachlorophene with opposite effects. The hexachlorophene modulation of Siah-1 and β-catenin is independent of p53 and results in reduced expression of cyclin-D1 and c-Myc (target genes of β-catenin), leading to the growth arrest of B lymphoma cells. From these results we propose that hexachlorophene may provide a novel therapeutic strategy for EBV-infected B lymphoma cells by reducing β-catenin levels via the restoration of Siah-1.
has issue date	2009-04-18(xsd:dateTime)
bibo:doi	10.1016/j.canlet.2008.10.041
bibo:pmid	19091460
has license	els-covid
sha1sum (hex)	6f922896f5ca5faf171912e7fda57cf1f631dd87
schema:url	https://doi.org/10.1016/j.canlet.2008.10.041
resource representing a document's title	Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells
has PubMed Central identifier	PMC7116996
has PubMed identifier	19091460
schema:publication	Cancer Letters
resource representing a document's body	covid:6f922896f5ca5faf171912e7fda57cf1f631dd87#body_text
is schema:about of	named entity 'Our' named entity 'b-catenin' named entity 'EBV' named entity 'p53' named entity 'cellular transformation' named entity 'elevated' named entity 'INFECTED' named entity 'LYMPHOMA CELLS' named entity 'LEADING' named entity 'REPORT' named entity 'USING' named entity 'EXPRESSION' named entity 'EBV' named entity 'CATENIN' named entity 'RECENT' named entity 'COLON CANCER' named entity 'PROMOTE' named entity 'CATENIN' named entity 'REGULATION' named entity 'CANCER CELLS' named entity 'TARGETED' named entity 'OF INTEREST' named entity 'EFFECTS' named entity 'LYMPHOMAS' named entity 'HEXACHLOROPHENE' covid:arg/6f922896f5ca5faf171912e7fda57cf1f631dd87 named entity 'SIAH-1' named entity 'NOVEL' named entity 'PROTEIN ' named entity 'GROWTH ARREST' named entity 'SIAH-1' named entity 'INFECTED' named entity 'DIMINISHED' named entity 'LATENT MEMBRANE PROTEIN' named entity 'WORK' named entity 'REDUCED' named entity 'BASED' named entity 'SUGGEST' named entity 'OPPOSITE' named entity 'THESE' named entity 'GENES' named entity 'E3 UBIQUITIN LIGASE' named entity 'LMP-1' named entity 'INFECTION' named entity 'REDUCING' named entity 'HEXACHLOROPHENE' named entity 'MODULATION' named entity 'ASSOCIATED WITH' named entity 'SUPPRESSES' named entity 'UP-REGULATION' named entity 'STRATEGY' named entity 'ELEVATED' named entity 'HAVE' named entity 'STUDIES' named entity 'ITS' named entity 'CELLULAR TRANSFORMATION' named entity 'LYMPHOMA CELLS' named entity 'REGULATE' named entity 'CELL' named entity 'LEVELS' named entity 'P53' named entity 'CYCLIN-D1' named entity 'ACTIVATION' named entity 'EXPRESSION' named entity 'MODULATE' named entity 'ANTIBIOTIC' named entity 'RESTORATION' named entity 'EPSTEIN-BARR VIRUS' named entity 'OUR' named entity 'PATHWAY' named entity 'ONCOGENESIS' named entity 'HERE'

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