About: Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke

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About: Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke
Creator	Ho, Koh, Young Choi, Ji-Young Chulman, Jo Ho, K Hyun, Park Munjin, Kwon Sun-Jung, Cho Cho, Sun-Jung Choi, Ji-Young † Chulman, J Hye-Kyung, L Hyun, P Lee, Hye-Kyung Lee, Hye-Kyung † Munjin, K Sun-Jung, C
source	Elsevier; Medline; PMC
abstract	Coronavirus disease 2019 (COVID-19) is a worldwide pandemic. It has a high transmission rate among humans, and is a threat to global public health. However, there are no effective prophylactics or therapeutics available. It is necessary to identify vulnerable and susceptible groups for adequate protection and care against this disease. Recent studies have reported that COVID-19 has angiotensin-converting enzyme 2 (ACE2) as a functional receptor, which may lead to the development of severe cerebrovascular diseases (CVD), including strokes, in patients with risk factors for CVD such as diabetes and smoking. Thus, the World Health Organization (WHO) advised caution against COVID-19 for smokers and patients with underlying clinical symptoms, including cardiovascular diseases. Here, we observed ACE2 expression in the brain of rat middle cerebral artery occlusion (MCAO) model and evaluated the effects of cigarette smoke extract (CSE) and diabetes on ACE2 expression in vessels. We showed that the levels of ACE2 expression was increased in the cortex penumbra after ischemic injuries. CSE treatment significantly elevated ACE2 expression in human brain vessels. We found that ACE2 expression was upregulated in primary cultured human blood vessels with diabetes compared to healthy controls. This study demonstrates that ACE2 expression is increased in ischemic brains and vessels exposed to diabetes or smoking, makes them vulnerable to COVID-19 infection.
has issue date	2020-05-29(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2020.05.203
bibo:pmid	32513532
has license	no-cc
sha1sum (hex)	703f007ae0d8234fb645209812115d5ea59c6fa8
schema:url	https://doi.org/10.1016/j.bbrc.2020.05.203
resource representing a document's title	Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke
has PubMed Central identifier	PMC7256621
has PubMed identifier	32513532
schema:publication	Biochem Biophys Res Commun
resource representing a document's body	covid:703f007ae0d8234fb645209812115d5ea59c6fa8#body_text
is schema:about of	named entity 'blood vessels' named entity 'CVD' named entity 'disease' named entity 'observed' named entity 'expression' named entity 'study' named entity 'higher' named entity 'Journal' named entity 'receptor' named entity 'HUMAN' named entity 'CULTURED' named entity 'LEAD' named entity 'DISEASE' named entity 'INCREASED' named entity 'DIABETES' named entity 'PROTECTION' named entity 'CARDIOVASCULAR DISEASES' named entity 'penumbra' named entity 'transmission' named entity 'humans' named entity 'levels' named entity 'smokers' named entity 'care' named entity 'compared' named entity 'This' named entity 'primary' named entity 'ACE2' named entity 'pandemic' named entity 'strokes' named entity 'COVID-19' named entity 'injuries' named entity 'expression' named entity 'cultured' named entity 'brains' named entity 'expression' named entity 'group' named entity 'ACE2' named entity 'ACE2' named entity 'diabetes' named entity 'clinical symptoms' named entity 'WHO' named entity 'rat' named entity 'ischemic' named entity 'COVID' named entity 'infection' named entity 'middle cerebral artery' named entity 'ACE2' named entity 'ACE2' named entity 'COVID' named entity 'diabetes' named entity 'COVID' named entity 'receptor' named entity 'diabetes' named entity 'Tris-HCl' named entity '21 days' named entity 'Blood clotting' named entity 'smokers' named entity 'cardiovascular disease' named entity 'diabetes' named entity 'myalgia' named entity 'ACE2' named entity 'polyvinylidene difluoride' named entity 'stroke' named entity 'ACE2' named entity 'SARS-CoV-2'

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