About: Serological evidence and experimental infection of cynomolgus macaques with pteropine orthoreovirus reveal monkeys as potential hosts for transmission to humans

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About: Serological evidence and experimental infection of cynomolgus macaques with pteropine orthoreovirus reveal monkeys as potential hosts for transmission to humans Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Serological evidence and experimental infection of cynomolgus macaques with pteropine orthoreovirus reveal monkeys as potential hosts for transmission to humans
Creator	Wang, Lin-Fa Mani, Shailendra Uehara, Anna Wittwer, Kevin Anderson, Danielle Chee, Wah Lim, Xiao Tan,
Source	PMC
abstract	Pteropine orthoreoviruses (PRV) are emerging bat-borne viruses with proven zoonotic transmission. We recently demonstrated human exposure to PRV in Singapore, which together with previous reports from Malaysia and Vietnam suggest that human infection of PRV may occur periodically in the region. This raises the question whether bats are the only sources of human infection. In this study, we screened 517 cynomolgus macaques caught in Singapore for evidence of exposure to PRV3M (also known as Melaka virus), which was first isolated from human patients in Melaka, Malaysia. We found that 67 serum samples were PRV3M positive by ELISA and 34 were also positive by virus neutralization assay. To investigate whether monkeys could act as hosts for PRV transmission, we experimentally infected cynomolgus macaques with PRV3M and housed these animals with uninfected monkeys. Although no clinical signs of infection were observed in infected animals, viral RNA was detected in nasal and rectal swabs and all infected macaques seroconverted. Additionally, one of the uninfected animals seroconverted, implying active shedding and transmission of PRV3M. We provide evidence that PRV exposure in the macaque population in Singapore occurs at a relatively high prevalence and this study suggests that cynomolgus macaques may be an intermediate or reservoir host for PRVs.
has issue date	2019-05-28(xsd:dateTime)
bibo:doi	10.1080/22221751.2019.1621668
bibo:pmid	31132935
has license	cc-by
sha1sum (hex)	70b27df77b5f3ef4c9be9028cc34110d4dd7d22b
schema:url	https://doi.org/10.1080/22221751.2019.1621668
resource representing a document's title	Serological evidence and experimental infection of cynomolgus macaques with pteropine orthoreovirus reveal monkeys as potential hosts for transmission to humans
has PubMed Central identifier	PMC6542153
has PubMed identifier	31132935
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:70b27df77b5f3ef4c9be9028cc34110d4dd7d22b#body_text
is schema:about of	named entity 'infected' named entity 'study' named entity 'animals' named entity 'infection' named entity 'experimental' named entity 'EXPERIMENTAL INFECTION' named entity 'TRANSMISSION' named entity 'MONKEYS' named entity 'VIETNAM' named entity 'REGION' named entity 'ANIMALS' named entity 'TRANSMISSION' named entity 'HUMAN EXPOSURE' named entity 'THESE' named entity 'VIRUS NEUTRALIZATION ASSAY' named entity 'EVIDENCE' named entity 'SINGAPORE' named entity 'RECENTLY' named entity 'KNOWN' named entity 'MAY BE' named entity 'NASAL' named entity 'EXPOSURE' named entity 'SERUM' named entity 'DEMONSTRATED' named entity 'STUDY' named entity 'TO INVESTIGATE' named entity 'INFECTION' named entity 'INTERMEDIATE' named entity 'BATS' named entity 'MALAYSIA' named entity 'EVIDENCE OF' named entity 'SOURCES' named entity 'EXPOSURE TO' named entity 'ACTIVE' named entity 'PRV' named entity 'HOSTS' named entity 'REVEAL' named entity 'PTEROPINE ORTHOREOVIRUS' named entity 'ACT' named entity 'FOUND' covid:arg/70b27df77b5f3ef4c9be9028cc34110d4dd7d22b named entity 'SWABS' named entity 'VIRAL RNA' named entity 'OBSERVED' named entity 'DETECTED' named entity 'BAT' named entity 'MACAQUES' named entity 'HUMANS' named entity 'SEROLOGICAL' named entity 'EVIDENCE' named entity 'MACAQUES' named entity 'POTENTIAL' named entity 'RESERVOIR' named entity 'PATIENTS' named entity 'ELISA' named entity 'HIGH PREVALENCE' named entity 'NO CLINICAL SIGNS' named entity 'UNINFECTED' named entity 'ONE OF' named entity 'PERIODICALLY' named entity 'POSITIVE' named entity 'SHEDDING' named entity 'SUGGEST' named entity 'PREVIOUS REPORTS' named entity 'VIRUSES' named entity 'HUMAN' named entity 'CYNOMOLGUS' named entity 'QUESTION' named entity 'POPULATION' named entity 'PROVIDE' named entity 'PROVEN' named entity 'HOST' named entity 'SAMPLES' named entity 'HOUSED'

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