About: Detection of Severe Acute Respiratory Syndrome–Associated Coronavirus in Pneumocytes of the Lung

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About: Detection of Severe Acute Respiratory Syndrome–Associated Coronavirus in Pneumocytes of the Lung Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Detection of Severe Acute Respiratory Syndrome–Associated Coronavirus in Pneumocytes of the Lung
Creator	Hsiao, Cheng-Hsiang Chow, Kuan-Chih Chiou, Shiow-Her Lin, Tze-Yi Chen, Chi-Long
source	Medline; PMC
abstract	Previous reports have indicated that patients with severe acute respiratory syndrome (SARS)–associated coronavirus infection could develop atypical pneumonia with fulminant pulmonary edema. However, the target cells of SARS viral infection have not been characterized in detail. We report the pathologic findings of the lung in 3 cases of SARS. Chest radiographs at 2 to 3 weeks of infection revealed an atypical pneumonia with pulmonary consolidation, a clinical characteristic of SARS infection. The presence of the SARS virus was determined by nested reverse transcription–polymerase chain reaction (RT-PCR), and the infected cells were identified by in situ hybridization in open-lung biopsy and postmortem necropsy specimens. Expression of SARS virus–encoded RNA was detected in all 3 cases by RT-PCR, and the SARS viral signal was localized in pneumocytes by using in situ hybridization.
has issue date	2004-04-01(xsd:dateTime)
bibo:doi	10.1309/c0edu0raqbtxbhce
bibo:pmid	15080310
has license	no-cc
sha1sum (hex)	7145144f4bd3e952f4e407d7a44558051234372d
schema:url	https://doi.org/10.1309/c0edu0raqbtxbhce
resource representing a document's title	Detection of Severe Acute Respiratory Syndrome–Associated Coronavirus in Pneumocytes of the Lung
has PubMed Central identifier	PMC7109992
has PubMed identifier	15080310
schema:publication	Am J Clin Pathol
resource representing a document's body	covid:7145144f4bd3e952f4e407d7a44558051234372d#body_text
is schema:about of	named entity 'LETHAL' named entity 'FAILURES' named entity 'ORGAN' named entity 'DYSPNEA' named entity 'ACUTE INFECTIOUS DISEASE' named entity 'CLINICAL MANIFESTATIONS' named entity 'SYSTEMIC' named entity 'SARS VIRUS' named entity 'DETECTION' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'LUNG' named entity 'INFECTIOUS DISEASE' named entity 'MICROBIOLOGY' named entity 'INFECTS' named entity 'ASSOCIATED' named entity 'CORONAVIRUS' named entity 'PNEUMOCYTES' named entity 'PROGRESSIVE' named entity 'ATYPICAL PNEUMONIA' named entity 'ABRUPT' named entity 'OXYGEN' named entity 'DISEASE' named entity 'DRY COUGH' named entity 'LOWER RESPIRATORY TRACT' named entity 'DETERIORATION OF LUNG FUNCTION' named entity 'STAGE' named entity 'PERSISTENT FEVER' named entity 'DEPRIVATION' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'ASSOCIATED' covid:arg/7145144f4bd3e952f4e407d7a44558051234372d named entity 'Severe acute respiratory syndrome' named entity 'lung function' named entity 'dry cough' named entity 'organ' named entity 'Pneumocytes' named entity 'endotracheal intubation' named entity 'multinucleated cell' named entity 'replicase' named entity 'human T-cell lymphotropic virus' named entity 'fever' named entity 'histiocytic necrotizing lymphadenitis' named entity 'cytoplasm' named entity 'histiocytes' named entity 'protein synthesis' named entity 'pulmonary edema' named entity 'SARS' named entity 'type II pneumocytes' named entity 'cytoplasm' named entity 'multinucleated giant cells' named entity 'antisense oligonucleotide' named entity 'infection' named entity 'foamy macrophages' named entity 'bona fide' named entity 'coronavirus' named entity 'lung' named entity 'alveolar epithelial cells' named entity 'SARS' named entity 'SARS' named entity 'nasopharyngeal carcinoma' named entity 'surfactant' named entity 'chemokines' named entity 'membrane protein' named entity 'antibodies' named entity 'conjugated' named entity 'lung' named entity 'epithelial cells' named entity 'nuclei' named entity 'ng/mL' named entity 'chemoattractive' named entity 'karyorrhexis' named entity 'immunohistochemical' named entity 'SARS' named entity 'lymphocytes' named entity 'hematoxylin' named entity 'type II pneumocyte' named entity 'ethanol'

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