About: SARS coronavirus: Unusual lability of the nucleocapsid protein

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About: SARS coronavirus: Unusual lability of the nucleocapsid protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	SARS coronavirus: Unusual lability of the nucleocapsid protein
Creator	Li, Xuguang Cyr, Terry Fournier, Sylvie Jaentschke, Bozena Mark, John Hefford, Mary
topic	covid:72267ff359743ab2f111042d9cc5f9dd5f14fe79#this
source	Elsevier; Medline; PMC
abstract	Abstract The severe acute respiratory syndrome (SARS) is a contagious disease that killed hundreds and sickened thousands of people worldwide between November 2002 and July 2003. The nucleocapsid (N) protein of the coronavirus responsible for this disease plays a critical role in viral assembly and maturation and is of particular interest because of its potential as an antiviral target or vaccine candidate. Refolding of SARS N-protein during production and purification showed the presence of two additional protein bands by SDS–PAGE. Mass spectroscopy (MALDI, SELDI, and LC/MS) confirmed that the bands are proteolytic products of N-protein and the cleavage sites are four SR motifs in the serine–arginine-rich region—sites not suggestive of any known protease. Furthermore, results of subsequent testing for contaminating protease(s) were negative: cleavage appears to be due to inherent instability and/or autolysis. The importance of N-protein proteolysis to viral life cycle and thus to possible treatment directions are discussed.
has issue date	2008-12-12(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2008.09.153
bibo:pmid	18926799
has license	els-covid
sha1sum (hex)	72267ff359743ab2f111042d9cc5f9dd5f14fe79
schema:url	https://doi.org/10.1016/j.bbrc.2008.09.153
resource representing a document's title	SARS coronavirus: Unusual lability of the nucleocapsid protein
has PubMed Central identifier	PMC7092863
has PubMed identifier	18926799
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:72267ff359743ab2f111042d9cc5f9dd5f14fe79#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/72267ff359743ab2f111042d9cc5f9dd5f14fe79
is schema:about of	named entity 'UNUSUAL' named entity 'NUCLEOCAPSID PROTEIN' named entity 'pro' named entity 'ing' named entity 'lytic' named entity 'protein' named entity 'SICK' named entity 'CAL' named entity 'V E' named entity 'SER' named entity 'DIS' named entity 'RUS' named entity 'PLAYS' named entity 'BLE' named entity 'DUC' named entity 'P I' named entity 'ACUTE' named entity 'CAP' named entity 'MOTIFS' named entity 'GES' named entity 'DATE' named entity 'PRO' named entity 'DUR' named entity 'COPY' named entity 'INTER' named entity 'IS A' named entity 'TIVE' named entity 'SYN' named entity 'S T' named entity 'PAR' named entity 'VAC' named entity 'O A' named entity 'SARS' named entity 'AGE' named entity 'RICH' named entity 'PURI' named entity 'TORY' named entity 'SARS CORONAVIRUS' named entity 'BANDS' named entity 'BER' named entity 'A T' named entity 'SUG' named entity 'POTENTIAL' named entity 'R T' named entity 'CINE' named entity 'SEL' named entity 'MAT' named entity 'PRES' named entity 'RAL' named entity 'SID' named entity 'WORLD' named entity 'UCTS' named entity 'EST' named entity 'WIDE' named entity 'ARGI' named entity 'HUN' named entity 'LAR' named entity 'ROLE' named entity 'SDS-PAGE' named entity 'INE' named entity 'MASS SPEC' named entity 'ASE' named entity 'SEVERE' named entity 'ITS' named entity 'PEOPLE' named entity 'EASE' named entity 'VIRAL' named entity 'CLEAV' named entity 'ENED' named entity 'DROME' named entity 'TAR' named entity 'PROD' named entity 'SITES' named entity 'REGION'

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