About: Acute Disseminated Encephalomyelitis with Seizures and Myocarditis: A Fatal Triad

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Acute Disseminated Encephalomyelitis with Seizures and Myocarditis: A Fatal Triad
Creator	Petzold, Axel Bahn, Erik Bertsche, Astrid Büttner, Andreas Däbritz, Jan Ehler, Johannes Hauenstein, Christina Lademann, Hanne Reuter, Daniel Spang, Christian Warnke, Philipp Zack, Fred
source	PMC
abstract	Autoimmune pathology of acute disseminated encephalomyelitis (ADEM) is generally restricted to the brain. Our objective is to expand the phenotype of ADEM. A four-year-old girl was admitted to the pediatric emergency room of a university medical center five days after a common upper respiratory tract infection. Acute symptoms were fever, leg pain, and headaches. She developed meningeal signs, and her level of consciousness dropped rapidly. Epileptic seizure activity started, and she became comatose, requiring intubation and mechanical ventilation. Serial brain magnetic resonance imaging (MRI) illustrated the fulminant development of ADEM. Treatment escalation with high-dose corticosteroids, immunoglobulins, and plasma exchange did not lead to clinical improvement. On day ten, the patient developed treatment-refractory cardiogenic shock and passed away. The postmortem assessment confirmed ADEM and revealed acute lymphocytic myocarditis, likely explaining the acute cardiac failure. Human metapneumovirus and picornavirus were detected in the tracheal secrete by PCR. Data sources–medical chart of the patient. This case is consistent with evidence from experimental findings of an association of ADEM with myocarditis as a postinfectious systemic autoimmune response, with life-threatening involvement of the brain and heart.
has issue date	2020-06-04(xsd:dateTime)
bibo:doi	10.3390/medicina56060277
bibo:pmid	32512953
has license	cc-by
sha1sum (hex)	730f4aa30b2cb9876229702f3aa7ae747d6e6d3b
schema:url	https://doi.org/10.3390/medicina56060277
resource representing a document's title	Acute Disseminated Encephalomyelitis with Seizures and Myocarditis: A Fatal Triad
has PubMed Central identifier	PMC7353866
has PubMed identifier	32512953
schema:publication	Medicina (Kaunas)
resource representing a document's body	covid:730f4aa30b2cb9876229702f3aa7ae747d6e6d3b#body_text
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