About: Investigation of Pathogenesis of H1N1 Influenza Virus and Swine Streptococcus suis Serotype 2 Co-Infection in Pigs by Microarray Analysis

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About: Investigation of Pathogenesis of H1N1 Influenza Virus and Swine Streptococcus suis Serotype 2 Co-Infection in Pigs by Microarray Analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Investigation of Pathogenesis of H1N1 Influenza Virus and Swine Streptococcus suis Serotype 2 Co-Infection in Pigs by Microarray Analysis
Creator	Shi, Jian Sun, Xin Huang, Canhui Jin, Meilin Lin, Xian Liu, Xiaokun Wang, Ruifang Zhao, Lianzhong Liu, Sun
Source	PMC
abstract	Swine influenza virus and Streptococcus suis are two important contributors to the porcine respiratory disease complex, and both have significant economic impacts. Clinically, influenza virus and Streptococcus suis co-infections in pigs are very common, which often contribute to severe pneumonia and can increase the mortality. However, the co-infection pathogenesis in pigs is unclear. In the present study, co-infection experiments were performed using swine H1N1 influenza virus and Streptococcus suis serotype 2 (SS2). The H1N1-SS2 co-infected pigs exhibited more severe clinical symptoms, serious pathological changes, and robust apoptosis of lungs at 6 days post-infection compared with separate H1N1 and SS2 infections. A comprehensive gene expression profiling using a microarray approach was performed to investigate the global host responses of swine lungs against the swine H1N1 infection, SS2 infection, co-infection, and phosphate-buffered saline control. Results showed 457, 411, and 844 differentially expressed genes in the H1N1, SS2, and H1N1-SS2 groups, respectively, compared with the control. Noticeably, genes associated with the immune, inflammatory, and apoptosis responses were highly overexpressed in the co-infected group. Pathway analysis indicated that the cytokine–cytokine receptor interactions, MAPK, toll-like receptor, complement and coagulation cascades, antigen processing and presentation, and apoptosis pathway were significantly regulated in the co-infected group. However, the genes related to these were less regulated in the separate H1N1 and SS2 infection groups. This observation suggested that a certain level of synergy was induced by H1N1 and SS2 co-infection with significantly stronger inflammatory and apoptosis responses, which may lead to more serious respiratory disease syndrome and pulmonary pathological lesion.
has issue date	2015-04-23(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0124086
bibo:pmid	25906258
has license	cc-by
sha1sum (hex)	73f93646de4efa4c3b8d02d07dea684c028763d1
schema:url	https://doi.org/10.1371/journal.pone.0124086
resource representing a document's title	Investigation of Pathogenesis of H1N1 Influenza Virus and Swine Streptococcus suis Serotype 2 Co-Infection in Pigs by Microarray Analysis
has PubMed Central identifier	PMC4407888
has PubMed identifier	25906258
schema:publication	PLoS One
resource representing a document's body	covid:73f93646de4efa4c3b8d02d07dea684c028763d1#body_text
is schema:about of	named entity 'STREPTOCOCCUS SUIS SEROTYPE 2' named entity 'genes' named entity 'common' named entity 'co-infection' named entity 'study' named entity 'pathological' named entity 'respiratory disease' named entity 'compared' named entity 'Streptococcus' named entity 'synergy' named entity 'H1N1' named entity 'separate' named entity 'Streptococcus' named entity 'investigate' named entity 'Investigation' named entity 'OPEN' named entity 'OPEN' named entity 'ANTIGEN PROCESSING AND PRESENTATION' named entity 'CO-INFECTION' named entity 'CO-INFECTIONS' named entity 'BUFFERED' named entity 'INFLUENZA VIRUS' named entity 'CONTRIBUTE ' named entity 'H1N1' named entity 'LEAD' named entity 'USING' named entity 'INFLAMMATORY' named entity 'LUNGS' named entity 'SEPARATE' named entity 'LEVEL' named entity 'RESPONSES' named entity 'SYNDROME' named entity 'ROBUST' named entity 'RECEPTOR INTERACTIONS' named entity 'PHOSPHATE' named entity 'GENES' named entity 'EXPRESSED' named entity 'INFECTED' named entity 'SWINE' named entity 'ACCESS' named entity 'H1N1 INFLUENZA' named entity 'PIGS' named entity 'APPROACH' named entity 'STUDY' named entity 'INFECTION' named entity 'COMMON' named entity 'RESPIRATORY DISEASE' named entity 'HOST' named entity 'PATHOGENESIS' named entity 'PIGS' named entity 'INDICATED' named entity 'ASSOCIATED WITH' named entity 'APOPTOSIS' named entity 'CONTROL' named entity 'GROUPS' named entity 'PRESENT' named entity 'SALINE' named entity 'CLINICAL SYMPTOMS' named entity 'GROUP' named entity 'TOLL-LIKE RECEPTOR' named entity 'UNCLEAR' named entity 'COMPLEX' named entity 'STREPTOCOCCUS SUIS SEROTYPE 2' named entity 'PATHWAY ANALYSIS' named entity 'ECONOMIC IMPACTS' named entity 'REGULATED' named entity 'IMMUNE' named entity 'IMPORTANT' named entity 'RESULTS' named entity 'COMPLEMENT AND COAGULATION CASCADES' named entity 'HAVE' named entity 'STREPTOCOCCUS SUIS' named entity 'OBSERVATION'

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