About: An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity

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About: An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity
Creator	Dodagatta-Marri, Eswari Kishore, Uday Nayak, Annapurna Daha, Mohamed Tsolaki, Anthony
topic	covid:74bc0b72bd1e1984f0428c90223d5f9cceda5f22#this
Source	Medline; PMC
abstract	Surfactant proteins SP-A and SP-D are hydrophilic, collagen-containing calcium-dependent lectins, which appear to have a range of innate immune functions at pulmonary as well as extrapulmonary sites. These proteins bind to target ligands on pathogens, allergens, and apoptotic cells, via C-terminal homotrimeric carbohydrate recognition domains, while the collagen region brings about the effector functions via its interaction with cell surface receptors. SP-A and SP-D deal with various pathogens, using a range of innate immune mechanisms such as agglutination/aggregation, enhancement of phagocytosis, and killing mechanisms by phagocytic cells and direct growth inhibition. SP-A and SP-D have also been shown to be involved in the control of pulmonary inflammation including allergy and asthma. Emerging evidence suggest that SP-A and SP-D are capable of linking innate immunity with adaptive immunity that includes modulation of dendritic cell function and helper T cell polarization. This review enumerates immunological properties of SP-A and SP-D inside and outside lungs and discusses their importance in human health and disease.
has issue date	2012-06-07(xsd:dateTime)
bibo:doi	10.3389/fimmu.2012.00131
bibo:pmid	22701116
has license	cc-by-nc
sha1sum (hex)	74bc0b72bd1e1984f0428c90223d5f9cceda5f22
schema:url	https://doi.org/10.3389/fimmu.2012.00131
resource representing a document's title	An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity
has PubMed Central identifier	PMC3369187
has PubMed identifier	22701116
schema:publication	Front Immunol
resource representing a document's body	covid:74bc0b72bd1e1984f0428c90223d5f9cceda5f22#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/74bc0b72bd1e1984f0428c90223d5f9cceda5f22
is schema:about of	named entity 'ADAPTIVE IMMUNITY' named entity 'SP-D' named entity 'lectins' named entity 'phagocytosis' named entity 'SP-A' named entity 'DIVERSE' named entity 'T CELL POLARIZATION' named entity 'IMMUNOLOGICAL' named entity 'COLLAGEN' named entity 'PATHOGENS' named entity 'OUTSIDE' named entity 'DIRECT' named entity 'TARGET' named entity 'SITES' named entity 'ENHANCEMENT' named entity 'CALCIUM' named entity 'RECOGNITION' named entity 'CELL SURFACE' named entity 'ITS' named entity 'C-TERMINAL' named entity 'VARIOUS' named entity 'EVIDENCE' named entity 'SP-D' named entity 'IMMUNE' named entity 'PROPERTIES' named entity 'PROTEINS' named entity 'INSIGHT' named entity 'SP-D' named entity 'REVIEW' named entity 'MODULATION' named entity 'SURFACTANT' named entity 'DEAL' named entity 'ALLERGENS' named entity 'LUNGS' named entity 'CELLS' named entity 'FUNCTIONS' named entity 'HAVE' named entity 'REGION' named entity 'HUMAN HEALTH' named entity 'KILLING' named entity 'ADAPTIVE IMMUNITY' named entity 'HEALTH AND DISEASE' named entity 'CONTROL' named entity 'SUGGEST' named entity 'LECTINS' named entity 'INSIDE' named entity 'PULMONARY INFLAMMATION' named entity 'ABOUT' named entity 'HELPER T CELL' named entity 'LIGANDS' named entity 'USING' named entity 'RECEPTORS' named entity 'MECHANISMS' named entity 'APOPTOTIC' named entity 'PULMONARY' named entity 'ROLES' named entity 'SP-A' named entity 'GROWTH INHIBITION' named entity 'HYDROPHILIC' named entity 'BIND' named entity 'INCLUDING' named entity 'ASTHMA' named entity 'INVOLVED' named entity 'DENDRITIC CELL FUNCTION' named entity 'SURFACTANT' named entity 'CARBOHYDRATE' named entity 'THEIR' named entity 'INTERACTION' named entity 'LINKING' named entity 'CONTAINING' named entity 'AGGLUTINATION' named entity 'APPEAR' named entity 'INNATE IMMUNITY' named entity 'PHAGOCYTOSIS' named entity 'ALLERGY'

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