About: Immune responses induced by recombinant Lactobacillus plantarum expressing the spike protein derived from transmissible gastroenteritis virus in piglets

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About: Immune responses induced by recombinant Lactobacillus plantarum expressing the spike protein derived from transmissible gastroenteritis virus in piglets Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immune responses induced by recombinant Lactobacillus plantarum expressing the spike protein derived from transmissible gastroenteritis virus in piglets
Creator	Feng, Bo Xie, Jing Wang, Guan Huang, Hai-Bin Huang, Ke-Yan Jiang, Yan-Long Jin, Yu-Bei Kang, Yuan-Huan Shi, Chun-Wei Wang, Chun-Feng Wang, Jian-Zhong Yang, Gui-Lian Yang, Wen-Tao Li, Qiong-Yan Zhao, Guang-Xun
Source	Medline; PMC
abstract	Transmissible gastroenteritis coronavirus (TGEV) is one of the most severe threats to the swine industry. In this study, we constructed a suite of recombinant Lactobacillus plantarum with surface displaying the spike (S) protein coming from TGEV and fused with DC cells targeting peptides (DCpep) to develop an effective, safe, and convenient vaccine against transmissible gastroenteritis. Our research results found that the recombinant Lactobacillus plantarum (NC8-pSIP409-pgsA-S-DCpep) group expressing S fused with DCpep could not only significantly increase the percentages of MHC-II(+)CD80(+) B cells and CD3(+)CD4(+) T cells but also the number of IgA(+) B cells and CD3(+)CD4(+) T cells of ileum lamina propria, which elevated the specific secretory immunoglobulin A (SIgA) titers in feces and IgG titers in serum. Taken together, these results suggest that NC8-pSIP409-pgsA-S-DCpep expressing the S of TGEV fused with DCpep could effectively induce immune responses and provide a feasible original strategy and approach for the design of TGEV vaccines.
has issue date	2018-07-18(xsd:dateTime)
bibo:doi	10.1007/s00253-018-9205-0
bibo:pmid	30022263
has license	no-cc
sha1sum (hex)	752d235f5288f9d902a914649f86dcffdd111561
schema:url	https://doi.org/10.1007/s00253-018-9205-0
resource representing a document's title	Immune responses induced by recombinant Lactobacillus plantarum expressing the spike protein derived from transmissible gastroenteritis virus in piglets
has PubMed Central identifier	PMC7080080
has PubMed identifier	30022263
schema:publication	Appl Microbiol Biotechnol
resource representing a document's body	covid:752d235f5288f9d902a914649f86dcffdd111561#body_text
is schema:about of	named entity 'BIOTECHNOLOGY' named entity 'gastroenteritis' named entity 'protein' named entity 'MHC-II' named entity 'ileum' named entity 'T cells' named entity 'gastroenteritis' named entity 'derived' named entity 'RECOMBINANT' named entity 'INDUCED' named entity 'APPLIED GENETICS' named entity 'CELLS' named entity 'VACCINE' named entity 'THREATS' named entity 'ILEUM' named entity 'FOUND' named entity 'PGSA' named entity 'FECES' named entity 'SPIKE' named entity 'RESEARCH RESULTS' named entity 'SWINE' named entity 'DESIGN' named entity 'PROVIDE' named entity 'FUSED WITH' named entity 'IGG' covid:arg/752d235f5288f9d902a914649f86dcffdd111561 named entity 'IMMUNE RESPONSES' named entity 'GASTROENTERITIS' named entity 'DERIVED' named entity 'TARGETING' named entity 'SERUM' named entity 'EFFECTIVE' named entity 'COMING' named entity 'PROTEIN ' named entity 'LACTOBACILLUS PLANTARUM' named entity 'MOLECULAR' named entity 'SPIKE PROTEIN' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'IMMUNE RESPONSES' named entity 'ONE OF' named entity 'STRATEGY' named entity 'TAKEN' named entity 'OUR' named entity 'INCREASE' named entity 'CONSTRUCTED' named entity 'FEASIBLE' named entity 'SECRETORY IMMUNOGLOBULIN A' named entity 'SUITE' named entity 'APPROACH' named entity 'PROTEIN ' named entity 'VACCINES' named entity 'RECOMBINANT' named entity 'IGA' named entity 'LAMINA PROPRIA' named entity 'RESULTS' named entity 'CD4' named entity 'BUT' named entity 'T CELLS' named entity 'PEPTIDES' named entity 'CD3' named entity 'CONVENIENT' named entity 'B CELLS' named entity 'LACTOBACILLUS PLANTARUM' named entity 'TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS' named entity 'MHC-II' named entity 'ELEVATED' named entity 'GROUP'

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