About: Targeting of endoplasmic reticulum-associated proteins to axons and dendrites in rotavirus-infected neurons

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Targeting of endoplasmic reticulum-associated proteins to axons and dendrites in rotavirus-infected neurons Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Targeting of endoplasmic reticulum-associated proteins to axons and dendrites in rotavirus-infected neurons
Creator	Svensson, Lennart Kristensson, Krister Weclewicz, Katarzyna
source	Elsevier; Medline; PMC
abstract	Abstract To analyze sorting and compartmentalization of molecules in neuronal endomembranes, the distribution of endogenous proteins associated with the endoplasmic reticulum (ER), intermediate compartment, the Golgi apparatus in cultures of dorsal root ganglion (DRG), and hippocampal neurons was compared with that of newly synthesized ER-associated rotavirus proteins. The endogenous ER-retained immunoglobulin heavy chain binding protein, protein disulfide isomerase, and a peptide containing the KDEL amino acid sequence appeared in the soma and dendrites up to their first branching, but not in axons. However, two other endogenous ER-associated proteins, calreticulin and calnexin, occurred in axons as well as in the somatodendritic domains. The ER-associated rotavirus proteins, VP7 and NSP4, were widely distributed in cell bodies and dendrites. The former appeared also in axons and its localization partially overlapped with that of calreticulin and calnexin. One intermediate compartment protein, ER-Golgi-intermediate compartment-protein-53 (ERGIC-53), extended beyond the first division of the dendrites and did not, as the small guanosine 5′-triphosphate (GTP)-binding protein rab2, appear in axons. The location of rab2 to small vesicles was distinct from that of rotavirus VP7. Cis /medial Golgi cistern proteins were restricted to the cell bodies and proximal dendrites. This study emphasizes the marked heterogeneity in the targeting to axons and dendrites of proteins associated with ER and intermediate compartments. Therefore, the composition of axonal ER-retained molecules differs from that in the soma and this variation may reflect differences in functions between the ER compartments. Viral proteins are useful reporters for such heterogeneities and rotavirus VP7 may be a tool to reveal sorting signals for targeting of vesicular proteins to axons via a nonclassical Golgi-independent mechanism. Such signals may also determine viral targeting to different regions of the brain.
has issue date	1998-07-01(xsd:dateTime)
bibo:doi	10.1016/s0361-9230(98)00013-6
bibo:pmid	9671265
has license	els-covid
sha1sum (hex)	75f4a5dd419292368c22ea83133201ab5b4551ab
schema:url	https://doi.org/10.1016/s0361-9230%2898%2900013-6
resource representing a document's title	Targeting of endoplasmic reticulum-associated proteins to axons and dendrites in rotavirus-infected neurons
has PubMed Central identifier	PMC7126376
has PubMed identifier	9671265
schema:publication	Brain Research Bulletin
resource representing a document's body	covid:75f4a5dd419292368c22ea83133201ab5b4551ab#body_text
is schema:about of	named entity 'location' named entity 'endogenous' named entity 'soma' named entity 'signals' named entity 'synthesized' covid:arg/75f4a5dd419292368c22ea83133201ab5b4551ab named entity 'VP7' named entity 'GTP' named entity 'protein disulfide isomerase' named entity 'brain' named entity 'cistern' named entity 'proteins' named entity 'partially' named entity 'One' named entity 'emphasizes' named entity 'protein' named entity 'mechanism' named entity 'reflect' named entity 'axons' named entity 'However' named entity 'endogenous' named entity 'signals' named entity 'KDEL' named entity 'dendrites' named entity 'Golgi' named entity 'rotavirus' named entity 'rotavirus' named entity 'axons' named entity 'VP7' named entity 'GTP' named entity 'soma' named entity 'dendrites' named entity 'rotavirus' named entity 'Golgi apparatus' named entity 'rab2' named entity 'smooth ER' named entity 'Trypsin' named entity 'antisera' named entity 'calnexin' named entity 'dendritic tree' named entity 'DRG' named entity 'rotavirus' named entity '1:200' named entity 'glycoproteins' named entity 'neurons' named entity 'KDEL sequence' named entity 'hippocampal neurons' named entity 'neurons' named entity 'BiP' named entity 'axons' named entity 'Nutrient' named entity 'dendrites' named entity 'neurons' named entity 'transmembrane' named entity 'dendrite' named entity 'rat' named entity 'Triton X-100' named entity 'fetal bovine serum' named entity 'cytoplasmic' named entity 'VP7' named entity 'neurons' named entity 'endogenous proteins' named entity 'Calreticulin' named entity 'integral membrane protein' named entity 'glycerol' named entity 'DRG' named entity 'infection' named entity 'VP7' named entity 'nerve cell' named entity 'trypsinized' named entity 'collagen' named entity 'rat' named entity 'VP7' named entity 'calreticulin' named entity 'BiP' named entity 'BiP' named entity 'Viral proteins' named entity 'antibodies' named entity 'somatodendritic'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software