About: Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter CORANOSMIA cohort study

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About: Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter CORANOSMIA cohort study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter CORANOSMIA cohort study
Creator	Rozenberg, Flore Papon, Jean-François Agnes, ; Bartier, Sophie Benjamin Verillaud, ; Bequignon, Emilie Bryn, Agnes Camhi, Yohan Canouï-Poitrine, Florence Cantin, Delphine Corré, Alain Etienne, Nicolas Haim-Boukobza, Stephanie Hamel, Anne-Laure Hautefort, Charlotte Layese, ; Layese, Richard Md, Bryn Nguyen, Yann Nevoux, Jérôme Salmon, Dominique Slama, Dorsaf Sourdeau, Elise Verillaud, Benjamin
source	Elsevier; Medline; PMC
abstract	OBJECTIVES: To determine the frequency of SARS-CoV-2 positive samples in a subset of patients consulting for primarily isolated acute (<7 days) loss of smell and to assess the diagnostic accuracy of olfactory/gustatory dysfunction for COVID-19 diagnosis in the overall population tested for COVID-19 in the same period. METHODS: Prospective multicentric cohort study in four olfactory ENT units and a screening center for COVID-19. RESULTS: i) Among a subset of 55 patients consulting for primarily loss of smell, we found that 51 (92.7%) had a COVID-19 positive test (median viral load of 28.8 cycle threshold). Loss of smell was mostly total (anosmia), rarely associated with nasal obstruction but associated with a taste disorder in 80%. Olfactory dysfunction occurred suddenly, either as first complaint. The majority of patients (72.9%) partially recovered the sense of smell within 15 days. ii) In a population of 1824 patients tested for COVID-19, the positive predictive value and the specificity of loss of smell and/or taste were 78.5% and 90.3% respectively (sensitivity (40.8%), negative predictive value (63.6%)). CONCLUSIONS: Self-reported loss of smell had a high predictive positive value to identify COVID-19. Making this sign well known publicly could help to adopt isolation measures and inform potential contacts.
has issue date	2020-07-07(xsd:dateTime)
bibo:doi	10.1016/j.jinf.2020.07.005
bibo:pmid	32650110
has license	no-cc
sha1sum (hex)	760a70060b35d57c5c26aab654889d1899322213
schema:url	https://doi.org/10.1016/j.jinf.2020.07.005
resource representing a document's title	Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter CORANOSMIA cohort study
has PubMed Central identifier	PMC7338860
has PubMed identifier	32650110
schema:publication	J Infect
resource representing a document's body	covid:760a70060b35d57c5c26aab654889d1899322213#body_text
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