About: Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication

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About: Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication
Creator	Arulselvan, Palanisamy Jan, Jia-Tsrong Kuo, Chih-Jung Kuo, Sheng-Chu Liang, Po-Huang Shyur, Lie-Fen Wen, Chih-Chun Wu, Jin-Bin Yang, Ning-Sun
source	Elsevier
abstract	Abstract Development of anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) agents is pivotal to prevent the reemergence of the life-threatening disease, SARS. In this study, more than 200 extracts from Chinese medicinal herbs were evaluated for anti-SARS-CoV activities using a cell-based assay that measured SARS-CoV-induced cytopathogenic effect (CPE) in vitro on Vero E6 cells. Six herbal extracts, one each from Gentianae Radix (龍膽 lóng dǎn; the dried rhizome of Gentiana scabra), Dioscoreae Rhizoma (山藥 shān yào; the tuber of Dioscorea batatas), Cassiae Semen (決明子 jué míng zǐ; the dried seed of Cassia tora) and Loranthi Ramus (桑寄生 sāng jì shēng; the dried stem, with leaf of Taxillus chinensis) (designated as GSH, DBM, CTH and TCH, respectively), and two from Rhizoma Cibotii (狗脊 gǒu jǐ; the dried rhizome of Cibotium barometz) (designated as CBE and CBM), were found to be potent inhibitors of SARS-CoV at concentrations between 25 and 200μg/ml. The concentrations of the six extracts needed to inhibit 50% of Vero E6 cell proliferation (CC50) and 50% of viral replication (EC50) were determined. The resulting selective index values (SI=CC50/EC50) of the most effective extracts CBE, GSH, DBM, CTH and TCH were>59.4,> 57.5,> 62.1,> 59.4, and>92.9, respectively. Among these extracts, CBM and DBM also showed significant inhibition of SARS-CoV 3CL protease activity with IC50 values of 39μg/ml and 44μg/ml, respectively. Our findings suggest that these six herbal extracts may have potential as candidates for future development of anti-SARS therapeutics.
has issue date	2011-12-31(xsd:dateTime)
bibo:doi	10.1016/s2225-4110(16)30055-4
has license	els-covid
sha1sum (hex)	76116971261957b1db71d20ab5a6bedbbaa9ac7d
schema:url	https://doi.org/10.1016/s2225-4110%2816%2930055-4
resource representing a document's title	Traditional Chinese medicine herbal extracts of Cibotium barometz, Gentiana scabra, Dioscorea batatas, Cassia tora, and Taxillus chinensis inhibit SARS-CoV replication
schema:publication	Journal of Traditional and Complementary Medicine
resource representing a document's body	covid:76116971261957b1db71d20ab5a6bedbbaa9ac7d#body_text
is schema:about of	named entity 'MEDICINE HERBAL' named entity 'CBM' named entity 'needed' named entity 'cell proliferation' named entity 'extracts' named entity 'SARS-CoV' named entity 'herbal' named entity 'GENTIANA SCABRA' named entity 'CELL PROLIFERATION' named entity 'DISEASE' named entity 'CELL-BASED ASSAY' named entity 'THESE' named entity 'DRIED' named entity 'CASSIA TORA' named entity 'DEVELOPMENT' named entity 'PROTEASE ACTIVITY' named entity 'CBE' named entity 'TO INHIBIT' named entity 'MEASURED' named entity 'SIGNIFICANT' named entity 'GENTIANAE RADIX' named entity 'MEDICINAL HERBS' named entity 'LEAF' named entity '92U' named entity 'EFFECTIVE' named entity '200' named entity 'VERO' named entity 'VERO E6 CELL' named entity 'EXTRACTS' named entity 'USING' named entity 'SUGGEST' named entity 'STEM' named entity 'CONCENTRATIONS' named entity 'DETERMINED' named entity 'DIOSCOREA BATATAS' named entity 'TRADITIONAL CHINESE MEDICINE' named entity 'DBM' named entity 'EXTRACTS' named entity 'EVALUATED' named entity 'CIBOTIUM BAROMETZ' named entity 'TAXILLUS CHINENSIS' named entity 'DIOSCOREA BATATAS' named entity 'CIBOTIUM BAROMETZ' named entity 'REPLICATION' named entity 'JOURNAL ' named entity 'FOUND' named entity 'TO PREVENT' named entity 'CASSIA TORA' named entity 'IN VITRO' named entity 'POTENTIAL' named entity 'INDUCED' named entity 'CYTOPATHOGENIC EFFECT' named entity 'INHIBITION' named entity 'ASSOCIATED' named entity 'TUBER' named entity 'CELLS' named entity 'SARS' named entity 'RAMUS' named entity 'CTH' named entity 'TCH' named entity 'THERAPEUTICS' named entity 'A CELL' named entity '50%' named entity '90%' named entity 'FINDINGS' named entity 'CHINESE' named entity 'MORE THAN' named entity 'HERBAL' named entity 'GSH' named entity 'VIRAL REPLICATION' named entity 'RESULTING' named entity 'ACTIVITIES' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'MAY HAVE' named entity 'TAXILLUS CHINENSIS' named entity 'OUR'

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