About: Pre-admission air pollution exposure prolongs the duration of ventilation in intensive care patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Pre-admission air pollution exposure prolongs the duration of ventilation in intensive care patients
Creator	Jorens, Philippe Bijnens, Esmée Cox, Bianca De Weerdt, Annick Jans, Margot Janssen, Bram Lefebvre, Wouter Nawrot, Tim Salawi, Omar Vanpoucke, Charlotte Verbrugghe, Walter
source	PMC
abstract	PURPOSE: Air pollutant exposure constitutes a serious risk factor for the emergence or aggravation of (existing) pulmonary disease. The impact of pre-intensive care ambient air pollutant exposure on the duration of artificial ventilation was, however, not yet established. METHODS: The medical records of 2003 patients, admitted to the intensive care unit (ICU) of the Antwerp University Hospital (Flanders, Belgium), who were artificially ventilated on ICU admission or within 48 h after admission, for the duration of at least 48 h, were analyzed. For each patient’s home address, daily air pollutant exposure [particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM(2.5)) and ≤ 10 µm (PM(10)), nitrogen dioxide (NO(2)) and black carbon (BC)] up to 10 days prior to hospital admission was modeled using a high-resolution spatial–temporal model. The association between duration of artificial ventilation and air pollution exposure during the last 10 days before ICU admission was assessed using distributed lag models with a negative binomial regression fit. RESULTS: Controlling for pre-specified confounders, an IQR increment in BC (1.2 µg/m(3)) up to 10 days before admission was associated with an estimated cumulative increase of 12.4% in ventilation duration (95% CI 4.7–20.7). Significant associations were also observed for PM(2.5), PM(10) and NO(2), with cumulative estimates ranging from 7.8 to 8.0%. CONCLUSION: Short-term ambient air pollution exposure prior to ICU admission represents an unrecognized environmental risk factor for the duration of artificial ventilation in the ICU. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-020-05999-3) contains supplementary material, which is available to authorized users.
has issue date	2020-03-17(xsd:dateTime)
bibo:doi	10.1007/s00134-020-05999-3
bibo:pmid	32185459
has license	no-cc
sha1sum (hex)	7667ffbb5f15de9361b13e86207d874d887a3f09
schema:url	https://doi.org/10.1007/s00134-020-05999-3
resource representing a document's title	Pre-admission air pollution exposure prolongs the duration of ventilation in intensive care patients
has PubMed Central identifier	PMC7224020
has PubMed identifier	32185459
schema:publication	Intensive Care Med
resource representing a document's body	covid:7667ffbb5f15de9361b13e86207d874d887a3f09#body_text
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