About: Cytomegalovirus and Aspergillus spp. coinfection in organ transplantation: a case report and review of the literature

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About: Cytomegalovirus and Aspergillus spp. coinfection in organ transplantation: a case report and review of the literature Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Cytomegalovirus and Aspergillus spp. coinfection in organ transplantation: a case report and review of the literature
Creator	Gaipov, Abduzhappar Biyik, Zeynep Cizmecioglu, Ahmet Genc, Nejdet Ozbek, Orhan Solak, Yalcin Yeksan, Mehdi
source	PMC
abstract	With the advent of potent immunosuppressive options, acute rejection episodes have decreased at the expense of increased incidence of opportunistic infections in solid organ recipients. In the absence of any preventive therapy, 30–75 % of transplant recipients develop cytomegalovirus (CMV) infection. Candida spp. and Aspergillus spp. account for more than 80 % of invasive fungal infections in solid organ recipients. This co-occurrence of two commonly seen opportunistic infections may end up in fatality. Here, we present a case of concomitant Aspergillus spp. and CMV infection and discuss the relevant literature. A 54-year-old male patient presented with fever, shortness of breath, and chest pain on the 9th posttransplant week after renal transplantation. CMV-DNA by polymerase chain reaction (PCR) was 1,680,000 copies/ml, thus, valganciclovir dose was increased. There were inspiratory crackles at both lung bases, and chest computed tomography (CT) revealed multiple fungal balls throughout the right lung. Galactomannan antigen was positive, and voriconazole and other antimicrobials were subsequently added to the treatment. At the end of the therapy, on control CT, pneumonic consolidation had disappeared, sputum cultures didn’t show Aspergillus spp., and CMV-DNA reduced to 700 copies/ml. The patient showed a favorable clinical response to combined treatment; fever, dyspnea, and pleuritic chest pain disappeared. Both CMV disease and aspergillosis may present as pulmonary disease; thus, the characterization of one may not preclude the search for the other and the timely initiation of treatment is of paramount importance for good outcomes.
has issue date	2012-11-09(xsd:dateTime)
bibo:doi	10.1007/s13730-012-0040-3
bibo:pmid	28509226
has license	no-cc
sha1sum (hex)	76a329e95456971efefd60241bb0a8af22a2f7a1
schema:url	https://doi.org/10.1007/s13730-012-0040-3
resource representing a document's title	Cytomegalovirus and Aspergillus spp. coinfection in organ transplantation: a case report and review of the literature
has PubMed Central identifier	PMC5413728
has PubMed identifier	28509226
schema:publication	CEN Case Rep
resource representing a document's body	covid:76a329e95456971efefd60241bb0a8af22a2f7a1#body_text
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