About: Dendritic Cell-Specific Antigen Delivery by Coronavirus Vaccine Vectors Induces Long-Lasting Protective Antiviral and Antitumor Immunity

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About: Dendritic Cell-Specific Antigen Delivery by Coronavirus Vaccine Vectors Induces Long-Lasting Protective Antiviral and Antitumor Immunity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Dendritic Cell-Specific Antigen Delivery by Coronavirus Vaccine Vectors Induces Long-Lasting Protective Antiviral and Antitumor Immunity
Creator	Thiel, Volker Ludewig, Burkhard Maier, Reinhard Cervantes-Barragan, Luisa Janda, Jozef Levy, Frederic Rohrlich, Pierre-Simon Romero, Pedro Sierro, Sophie Speiser, Daniel Züst, Roland
source	Medline; PMC
abstract	Efficient vaccination against infectious agents and tumors depends on specific antigen targeting to dendritic cells (DCs). We report here that biosafe coronavirus-based vaccine vectors facilitate delivery of multiple antigens and immunostimulatory cytokines to professional antigen-presenting cells in vitro and in vivo. Vaccine vectors based on heavily attenuated murine coronavirus genomes were generated to express epitopes from the lymphocytic choriomeningitis virus glycoprotein, or human Melan-A, in combination with the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). These vectors selectively targeted DCs in vitro and in vivo resulting in vector-mediated antigen expression and efficient maturation of DCs. Single application of only low vector doses elicited strong and long-lasting cytotoxic T-cell responses, providing protective antiviral and antitumor immunity. Furthermore, human DCs transduced with Melan-A-recombinant human coronavirus 229E efficiently activated tumor-specific CD8(+) T cells. Taken together, this novel vaccine platform is well suited to deliver antigens and immunostimulatory cytokines to DCs and to initiate and maintain protective immunity.
has issue date	2010-09-14(xsd:dateTime)
bibo:doi	10.1128/mbio.00171-10
bibo:pmid	20844609
has license	no-cc
sha1sum (hex)	777328a5bc26d551df06e62b64682c03c25dde03
schema:url	https://doi.org/10.1128/mbio.00171-10
resource representing a document's title	Dendritic Cell-Specific Antigen Delivery by Coronavirus Vaccine Vectors Induces Long-Lasting Protective Antiviral and Antitumor Immunity
has PubMed Central identifier	PMC2939679
has PubMed identifier	20844609
schema:publication	mBio
resource representing a document's body	covid:777328a5bc26d551df06e62b64682c03c25dde03#body_text
is schema:about of	named entity 'vaccine' named entity 'express' named entity 'targeting' named entity 'Antigen' named entity 'IN VITRO' named entity 'HUMAN' named entity 'ANTIGEN TARGETING' named entity 'HERE' named entity 'IN VIVO' named entity 'MELAN-A' named entity 'CYTOKINES' named entity 'GLYCOPROTEIN' named entity 'ANTIGEN DELIVERY' named entity 'LONG' named entity 'VECTORS' named entity 'CORONAVIRUS' named entity 'REPORT' named entity 'GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR' named entity 'SPECIFIC ANTIGEN' named entity 'CYTOKINE ' covid:arg/777328a5bc26d551df06e62b64682c03c25dde03 named entity 'CORONAVIRUS VACCINE' named entity 'IMMUNITY' named entity 'DENDRITIC CELL' named entity 'ANTITUMOR' named entity 'SPECIFIC ANTIGEN' named entity 'ANTIGEN-PRESENTING CELLS' named entity 'BASED' named entity 'GENERATED' named entity 'MULTIPLE' named entity 'COMBINATION' named entity 'ANTIGENS' named entity 'EFFICIENT' named entity 'GENOMES' named entity 'LYMPHOCYTIC CHORIOMENINGITIS VIRUS' named entity 'ANTIVIRAL' named entity 'MURINE CORONAVIRUS' named entity 'VECTORS' named entity 'VACCINE' named entity 'PROFESSIONAL' named entity 'DENDRITIC CELLS' named entity 'ATTENUATED' named entity 'TO EXPRESS' named entity 'INFECTIOUS AGENTS' named entity 'TUMORS' named entity 'VACCINATION' named entity 'EPITOPES' named entity 'DELIVERY' named entity 'multiple' named entity 'epitopes' named entity 'cytokines' named entity 'infectious agents' named entity 'lymphocytic choriomeningitis virus' named entity 'genomes' named entity 'vectors' named entity 'antigens' named entity 'lymphocytic choriomeningitis virus' named entity 'immunostimulatory' named entity 'Vaccine' named entity 'genomes' named entity 'dendritic cells' named entity 'glycoprotein' named entity 'Dendritic Cell' named entity 'DCs' named entity 'bone marrow' named entity 'vector' named entity 'lymph nodes' named entity 'France' named entity 'MHV' named entity 'cloned' named entity 'coronaviruses'

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