About: The impact of laryngopharyngeal reflux disease on 95 hospitalized patients with COVID‐19 in Wuhan, China: A retrospective study

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About: The impact of laryngopharyngeal reflux disease on 95 hospitalized patients with COVID‐19 in Wuhan, China: A retrospective study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The impact of laryngopharyngeal reflux disease on 95 hospitalized patients with COVID‐19 in Wuhan, China: A retrospective study
Creator	Lin, Yong Li, Qing Cai, Yanping Li, Yanping Xue, \| Correspondence, Keying Jiang, Guiyuan Ke, Mingyao Md, Yi Xu, Jingqing Xue, Xue, Keying
Source	Medline; PMC
abstract	Studies have demonstrated that comorbidities, especially cardiovascular and endocrine diseases, correlated with poorer clinical outcomes. However, the impact of digestive system diseases has not been issued. The aim of this study is to determine the impact of laryngopharyngeal reflux disease (LPRD) on hospitalized patients with coronavirus disease 2019 (COVID‐19). We extracted clinical data regarding 95 patients in Wuhan Jinyintan Hospital, Wuhan, China, between 26 January and 21 February 2020. The Reflux Symptom Index (RSI) was used to assess the presence and severity of LPRD. An RSI greater than 13 is considered to be abnormal. A total of 95 patients with COVID‐19 were enrolled, with 61.1% (58/95), 32.6% (31/95), and 6.3% (6/95) being moderately ill, severely ill, and critically ill, respectively. In this study, 38.9% (37/95) of the patient had an RSI score over 13, which was indicative of LPRD. In univariable analysis, the age and RSI scores of severely or critically ill patients were statistically significantly higher than patients with moderate disease (P = .026 and P = .005, respectively). After controlling for age difference in a multivariable model, the RSI greater than 13, compared to RSI equal to 0, was associated with significantly higher risk of severe infection (P < .001; odds ratio [OR] = 11.411; 95% confidence interval [CI], 2.95‐42.09) and critical infection (P = .028; OR= 19.61; 95% CI, 1.38‐277.99). Among hospitalized patients with COVID‐19, RSI scores greater than 13, indicative of LPRD, correlated with poorer clinical outcomes. The prevalence of LPRD may be higher than the general population, which indicated that COVID‐19 can impair the upper esophageal sphincter and aggravate reflux.
has issue date	2020-06-02(xsd:dateTime)
bibo:doi	10.1002/jmv.25998
bibo:pmid	32396239
has license	no-cc
sha1sum (hex)	782ca995d5e53d6412b5844322e0c77f01e0db8e
schema:url	https://doi.org/10.1002/jmv.25998
resource representing a document's title	The impact of laryngopharyngeal reflux disease on 95 hospitalized patients with COVID‐19 in Wuhan, China: A retrospective study
has PubMed Central identifier	PMC7272861
has PubMed identifier	32396239
schema:publication	J Med Virol
resource representing a document's body	covid:782ca995d5e53d6412b5844322e0c77f01e0db8e#body_text
is schema:about of	named entity 'model' named entity 'Index' named entity 'digestive system' named entity 'study' named entity 'RSI' named entity 'moderate' named entity 'COVID-19' named entity 'INFECTION' named entity 'indicative' named entity 'greater' named entity 'Wuhan' named entity 'demonstrated' named entity 'coronavirus disease 2019' named entity 'diseases' named entity 'study' named entity 'disease' named entity 'statistically significantly' named entity 'infection' named entity 'clinical data' named entity 'upper esophageal sphincter' named entity 'COVID' named entity 'retrospective study' named entity 'laryngopharyngeal reflux' named entity 'Wuhan' named entity 'epidemiological' named entity 'SARS-CoV-2' named entity 'receptor' named entity 'SARS-CoV-2' named entity 'SARS-CoV-2' named entity 'postnasal drip' named entity 'cough' named entity 'COVID' named entity 'clinically significant' named entity 'general population' named entity 'COVID' named entity 'comorbidity' named entity 'mucus' named entity 'vasoactive medications' named entity 'oxygen saturation' named entity 'septic shock' named entity 'laryngopharyngeal reflux disease' named entity 'indigestion' named entity 'coughing' named entity 'comorbidities' named entity 'risk factors' named entity 'stomach acid' named entity 'COVID' named entity 'Nausea' named entity 'cardiovascular diseases' named entity 'vomiting' named entity 'Corona Virus Disease' named entity 'larynx' named entity 'COVID' named entity 'COVID' named entity 'esophagus' named entity 'motility' named entity 'critically ill' named entity 'polymerase chain reaction' named entity 'significant difference' named entity 'virus' named entity 'reflux' named entity 'digestive disorder' named entity 'computed tomography' named entity 'COVID' named entity 'meta-analysis' named entity 'comorbidity' named entity 'breathing difficulties' named entity 'reflux' named entity 'larynx' named entity 'Symptom'

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