About: Identification of gammaherpesvirus infection in free-ranging black bears (Ursus americanus)

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About: Identification of gammaherpesvirus infection in free-ranging black bears (Ursus americanus) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of gammaherpesvirus infection in free-ranging black bears (Ursus americanus)
Creator	Xu, Dan Kiupel, Matti Gilbert, Martin Troyer, Ryan Jin, Ling Yuan, Junfa Bildfell, Rob Black, Wendy Coutu, Jesse Wang, Sunny Wolff, Peregrine Wong, Karsten Maes, Roger Wise, Annabel
Source	Elsevier; Medline; PMC
abstract	Abstract Herpesvirus infection was investigated in black bears (Ursus americanus) with neurological signs and brain lesions of nonsuppurative encephalitis of unknown cause. Visible cytopathic effects (CPE) could only be observed on days 3–5 post-infection in HrT-18G cell line inoculated with bear tissue extracts. The observed CPE in HrT-18G cells included syncytia, intranuclear inclusions, and cell detachments seen in herpesvirus infection in vitro. Herpesvirus-like particles were observed in viral culture supernatant under the electron microscope, however, capsids ranging from 60 nm to 100 nm in size were often observed in viral cultures within the first two passages of propagation. Herpesvirus infection in the bear tissues and tissue cultures were detected by PCR using degenerate primers specific to the DNA polymerase gene (DPOL) and glycoprotein B gene (gB). DNA sequencing of the amplicon revealed that the detected herpesvirus has 94–95% identity to Ursid gammaherpesvirus 1 (UrHV-1) DNA sequences of DPOL. Phylogenetic analysis of DPOL sequences indicates that black bear herpesviruses and UrHV-1 are closely related and have small distances to members of Rhadinovirus. Interestingly, black bear herpesvirus infections were also found in bears without neurological signs. The DPOL DNA sequence of black bear herpesviruses detected in neurological bears were similar to the those detected in the non-neurological bears. However, the gB DNA sequence detected from the neurological bear is different from non-neurological bear and has only 64.5%–70% identity to each other. It is possible that at least two different types of gammaherpesviruses are present in the U. americanus population or several gammaherpesviruses exist in ursine species.
has issue date	2019-01-02(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2018.10.016
bibo:pmid	30385363
has license	els-covid
sha1sum (hex)	78ad087814896941614b7fdd6348a7f3deaf33ba
schema:url	https://doi.org/10.1016/j.virusres.2018.10.016
resource representing a document's title	Identification of gammaherpesvirus infection in free-ranging black bears (Ursus americanus)
has PubMed Central identifier	PMC7114836
has PubMed identifier	30385363
schema:publication	Virus Research
resource representing a document's body	covid:78ad087814896941614b7fdd6348a7f3deaf33ba#body_text
is schema:about of	named entity 'GAMMAHERPESVIRUS' named entity 'days' named entity 'particles' named entity 'viral' named entity 'brain lesions' named entity 'herpesviruses' named entity 'DNA sequencing' named entity 'extracts' named entity 'species' named entity 'amplicon' named entity 'infection' named entity 'FREE' named entity 'SIMILAR' named entity 'DAYS' named entity 'BRAIN LESIONS' named entity 'DAMANIA' named entity 'DISTANCES' named entity 'BLACK BEAR' named entity 'VIRAL CULTURE' named entity '100' named entity 'HERPESVIRUS INFECTIONS' named entity 'PCR' named entity 'UNKNOWN CAUSE' named entity 'BEAR' named entity 'SPECIFIC' named entity 'HERPESVIRUSES' named entity 'NEUROLOGICAL' named entity 'INCLUDED' named entity 'INTRANUCLEAR' named entity 'CYTOPATHIC EFFECTS' named entity '70%' named entity 'USING' named entity 'PRIMARY EFFUSION LYMPHOMA' named entity 'REVEALED' named entity 'POPULATION' named entity 'DNA SEQUENCES' named entity 'DNA POLYMERASE' named entity 'OBSERVED' named entity 'CULTURE SUPERNATANT' named entity 'RHADINOVIRUS' named entity 'IDENTITY' named entity 'SEEN' named entity 'NON-' named entity 'DNA SEQUENCE' named entity 'HAVE' named entity 'POSSIBLE' named entity 'HERPESVIRUS' named entity 'BLACK' named entity 'TYPES' named entity 'CAPSIDS' named entity 'HHV-4' named entity 'GLYCOPROTEIN B' named entity 'HRT-18G CELL' named entity 'PARTICLES' named entity 'TISSUE CULTURES' named entity 'PHOMA' named entity 'DETECTED' named entity 'CPE' named entity 'INCLUSIONS' named entity 'HUMAN' named entity 'TISSUES' named entity 'VIRAL' named entity 'DNA SEQUENCING' named entity 'URSID GAMMAHERPESVIRUS 1' named entity 'SIZE' named entity 'SEQUENCES' named entity 'PROPAGATION' named entity 'RELATED'

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