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About:
Progressive worsening of the respiratory and gut microbiome in children during the first two months of COVID-19
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schema:ScholarlyArticle
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wasabi.inria.fr
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Type:
Academic Article
research paper
schema:ScholarlyArticle
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Progressive worsening of the respiratory and gut microbiome in children during the first two months of COVID-19
Creator
Zhang, Chiyu
Zhang, Tao
Jin, Xia
Xu, Jin
Zeng, Mei
Xu, Rong
Zhang, Zhigang
Ma, Yingying
Xu,
Wu, Qunfu
Liu, Pengcheng
Or, Jin
source
MedRxiv
abstract
Children are less susceptible to COVID-19 and manifests lower morbidity and mortality after infection, for which a multitude of mechanisms may be proposed. Whether the normal development of gut-airway microbiome is affected by COVID-19 has not been evaluated. We demonstrate that COVID-19 alters the respiratory and gut microbiome of children. Alteration of the microbiome was divergent between the respiratory tract and gut, albeit the dysbiosis was dominated by genus Pseudomonas and sustained for up to 25-58 days in different individuals. The respiratory microbiome distortion persisted in 7/8 children for at least 19-24 days after discharge from the hospital. The gut microbiota showed early dysbiosis towards later restoration in some children, but not others. Disturbed development of both gut and respiratory microbiomes, and prolonged respiratory dysbiosis in children imply possible long-term complications after clinical recovery from COVID-19, such as predisposition to an increased health risk in the post-COVID-19 era.
has issue date
2020-07-17
(
xsd:dateTime
)
bibo:doi
10.1101/2020.07.13.20152181
has license
medrxiv
sha1sum (hex)
7939f331bd1166a3bf27c163166f2f2d443d72bd
schema:url
https://doi.org/10.1101/2020.07.13.20152181
resource representing a document's title
Progressive worsening of the respiratory and gut microbiome in children during the first two months of COVID-19
resource representing a document's body
covid:7939f331bd1166a3bf27c163166f2f2d443d72bd#body_text
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schema:about
of
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named entity 'respiratory'
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named entity 'normal'
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named entity 'dysbiosis'
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named entity 'gut'
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named entity 'nasal swab'
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