About: Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection
Creator	Bansal, Sandhya Gunasekaran, Muthukumar Hachem, Ramsey Mohanakumar, Thalachallour Omar, Ashraf Perincheri, Sudhir Ravichandran, Ranjithkumar Rodriguez, Francisco Sharma, Monal Smith, Michael Bremner, Ross Fisher, Cynthia Limaye, Ajit
source	Elsevier; Medline; PMC
abstract	BACKGROUND Respiratory viral infections can increase the risk of chronic lung allograft dysfunction after lung transplantation, but the mechanisms are unknown. In this study, we determined whether symptomatic respiratory viral infections after lung transplantation induce circulating exosomes that contain lung-associated self-antigens and assessed whether these exosomes activate immune responses to self-antigens. METHODS Serum samples were collected from lung transplant recipients with symptomatic lower- and upper-tract respiratory viral infections and from non-symptomatic stable recipients. Exosomes were isolated via ultracentrifugation; purity was determined using sucrose cushion; and presence of lung self-antigens, 20S proteasome, and viral antigens for rhinovirus, coronavirus, and respiratory syncytial virus were determined using immunoblot. Mice were immunized with circulating exosomes from each group and resulting differential immune responses and lung histology were analyzed. RESULTS Exosomes containing self-antigens, 20S proteasome, and viral antigens were detected at significantly higher levels (p < 0.05) in serum of recipients with symptomatic respiratory viral infections (n = 35) as compared with stable controls (n = 32). Mice immunized with exosomes from recipients with respiratory viral infections developed immune responses to self-antigens, fibrosis, small airway occlusion, and significant cellular infiltration; mice immunized with exosomes from controls did not (p < 0.05). CONCLUSIONS Circulating exosomes isolated from lung transplant recipients diagnosed with respiratory viral infections contained lung self-antigens, viral antigens, and 20S proteasome and elicited immune responses to lung self-antigens that resulted in development of chronic lung allograft dysfunction in immunized mice.
has issue date	2020-04-30(xsd:dateTime)
bibo:doi	10.1016/j.healun.2019.12.009
bibo:pmid	32033844
has license	els-covid
sha1sum (hex)	79b207dad88813efd15891fd9f4c62c19d3a9f69
schema:url	https://doi.org/10.1016/j.healun.2019.12.009
resource representing a document's title	Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection
has PubMed Central identifier	PMC7102671
has PubMed identifier	32033844
schema:publication	The Journal of Heart and Lung Transplantation
resource representing a document's body	covid:79b207dad88813efd15891fd9f4c62c19d3a9f69#body_text
is schema:about of	named entity 'immunized' named entity 'Exosomes' named entity 'small' named entity 'dysfunction' named entity 'rhinovirus' named entity 'higher' named entity 'exosomes' named entity 'induce' named entity 'risk' named entity 'ORIGINAL' named entity 'CHRONIC REJECTION' named entity 'ACTIVATE' named entity 'EXOSOMES' named entity 'UPPER' named entity 'VIRAL INFECTIONS' named entity 'CUSHION' named entity 'RHINOVIRUS' named entity 'MECHANISMS' named entity 'STABLE' named entity 'LEVELS' named entity 'CHRONIC LUNG ALLOGRAFT DYSFUNCTION' named entity 'TRACT' named entity 'PURITY' named entity 'DEVELOPMENT' named entity 'SYMPTOMATIC' named entity 'DIAGNOSED' named entity 'ISOLATED' named entity 'DETERMINED' named entity 'SUCROSE' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'LUNG TRANSPLANTATION' named entity 'LUNG TRANSPLANT' named entity 'CORONAVIRUS' named entity 'METHODS' named entity 'RESULTING' named entity 'UNKNOWN' named entity 'CONTAIN' named entity 'CONCLUSIONS' named entity 'DIFFERENTIAL' named entity 'IMMUNOBLOT' named entity 'NON-' named entity 'IMMUNIZED' named entity 'OCCLUSION' named entity 'LUNG TRANSPLANTATION' named entity 'RESPIRATORY VIRAL INFECTION' named entity 'COMPARED' named entity 'BACKGROUND' named entity 'FIBROSIS' named entity 'HIGHER' named entity 'PRE-CLINICAL' named entity 'INDUCE' named entity 'THESE' named entity 'LOWER' named entity 'EXOSOMES' named entity 'SCIENCE' named entity 'RESULTS' named entity 'CELLULAR INFILTRATION' named entity 'SERUM' named entity 'INCREASE' named entity 'ASSESSED' named entity 'ASSOCIATED' named entity 'MICE' named entity 'TRIGGER' named entity 'SMALL' named entity 'CONTAINING' named entity 'ULTRACENTRIFUGATION' named entity 'CIRCULATING' named entity 'BUT' named entity 'PRESENCE OF'

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