About: Genes involved in mitochondrial biogenesis and function may not show synchronised responses to mitochondria in shell gland of laying chickens under infectious bronchitis virus challenge

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About: Genes involved in mitochondrial biogenesis and function may not show synchronised responses to mitochondria in shell gland of laying chickens under infectious bronchitis virus challenge Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Genes involved in mitochondrial biogenesis and function may not show synchronised responses to mitochondria in shell gland of laying chickens under infectious bronchitis virus challenge
Creator	Roberts, Juliet Wu, Shu-Biao Khan, Samiullah
topic	covid:79d2ee55b54d57041ab6d9a3ecac33bc98d11ff5#this
source	Medline; PMC
abstract	BACKGROUND: Egg formation takes place in the oviduct of laying hens over a 24 h period. Infectious bronchitis virus (IBV) causes pathological lesions in the chicken oviduct. In the current study, mitochondrial counts were determined in three different segments of the oviduct during egg formation in laying chickens challenged with IBV T strain. Nuclear DNA encoded genes that are involved in mitochondrial biogenesis, fission and function were studied in the shell gland of the oviduct undergoing virus multiplication. RESULTS: In the shell gland, the mitochondrial count was significantly lower (P < 0.05) in the challenged group, compared with the control group. However, it did not vary in response to IBV challenge in the isthmus and magnum regions of the oviduct. The gene succinate dehydrogenase complex, subunit A, flavoprotein variant (SDHA) was down-regulated in the shell gland by IBV challenge (P < 0.05), while other genes being studied did not show responses to the challenge (P > 0.05). Differential expression of the genes was observed at different time-points of egg-shell formation. The expression levels of citrate synthase (CS), cytochrome C, somatic (CYC, S) and sodium-potassium adenosine triphosphatase (Na(+)-K(+)ATPase) genes were significantly higher, while those of SDHA and dynamin related protein 1 (Drp1) genes were significantly lower, at 15 h compared with 5 h following oviposition of the previous egg. The expression level of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) did not show significant change at different time-points. CONCLUSIONS: It was concluded that IBV T strain infection in laying hens reduced mitochondrial counts only in the shell gland region of the oviduct. The genes involved in mitochondrial biogenesis or function may not show synchronised responses to that of mitochondria in the shell gland of chickens under T strain of IBV challenge.
has issue date	2019-04-01(xsd:dateTime)
bibo:doi	10.1186/s12860-019-0190-7
bibo:pmid	31041887
has license	cc-by
sha1sum (hex)	79d2ee55b54d57041ab6d9a3ecac33bc98d11ff5
schema:url	https://doi.org/10.1186/s12860-019-0190-7
resource representing a document's title	Genes involved in mitochondrial biogenesis and function may not show synchronised responses to mitochondria in shell gland of laying chickens under infectious bronchitis virus challenge
has PubMed Central identifier	PMC6446503
has PubMed identifier	31041887
schema:publication	BMC Mol Cell Biol
resource representing a document's body	covid:79d2ee55b54d57041ab6d9a3ecac33bc98d11ff5#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/79d2ee55b54d57041ab6d9a3ecac33bc98d11ff5
is schema:about of	named entity 'current' named entity 'determined' named entity 'formation' named entity 'study' named entity 'infectious bronchitis' named entity 'NUCLEAR DNA' named entity 'STRAIN' named entity 'LAYING' named entity 'GENES' named entity 'CHICKENS' named entity 'CHICKENS' named entity 'DIFFERENT' named entity 'STUDY' named entity 'HENS' named entity 'RESPONSES' named entity 'CHALLENGE' named entity 'ENCODED' named entity 'CHICKEN' named entity 'PATHOLOGICAL' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'VIRUS MULTIPLICATION' named entity 'SHELL GLAND' named entity 'INVOLVED' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'GENES' named entity 'SHELL GLAND' named entity 'MITOCHONDRIAL BIOGENESIS' named entity 'LAYING' named entity 'FUNCTION' named entity 'CURRENT' named entity 'INVOLVED' named entity 'PLACE' named entity 'CAUSES' named entity 'OVIDUCT' named entity 'COUNTS' named entity 'LESIONS' named entity 'FUNCTION' named entity 'MITOCHONDRIAL BIOGENESIS' named entity 'SEGMENTS' named entity 'EGG FORMATION' named entity 'FISSION' named entity 'PERIOD' named entity 'BACKGROUND' named entity 'MITOCHONDRIA' named entity 'MITOCHONDRIAL' named entity 'DETERMINED' covid:arg/79d2ee55b54d57041ab6d9a3ecac33bc98d11ff5 named entity 'chickens' named entity 'chicken' named entity 'oviduct' named entity 'Nuclear DNA' named entity 'synchronised' named entity 'Nuclear DNA' named entity 'oviduct' named entity 'chicken' named entity 'oviduct' named entity 'GAPDH' named entity 'Mitochondrial fission' named entity 'denaturation' named entity 'gene expression' named entity 'expression levels' named entity 'virus' named entity 'Drp1' named entity 'RNA' named entity 'helicase' named entity 'gradient' named entity 'coactivator' named entity 'HeLa cells' named entity '37°C' named entity 'IBV' named entity 'RNA extraction' named entity 'viral load' named entity 'Australia' named entity 'translocation' named entity 'low temperature' named entity 'CYC' named entity 'mtDNA'

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