About: Immunization with Live Human Rhinovirus (HRV) 16 Induces Protection in Cotton Rats against HRV14 Infection

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About: Immunization with Live Human Rhinovirus (HRV) 16 Induces Protection in Cotton Rats against HRV14 Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunization with Live Human Rhinovirus (HRV) 16 Induces Protection in Cotton Rats against HRV14 Infection
Creator	Wang, Ji Bartlett, Nathan Kajon, Adriana Blanco, Jorge Boukhvalova, Marina Mclean, Gary Patel, Mira Pletneva, Lioubov Vogel, Stefanie Ae, Kajon Jcg, Blanco Lm, Pletneva Mc, Patel Sn, Vogel
Source	Medline; PMC
abstract	Human rhinoviruses (HRVs) are the main cause of cold-like illnesses, and currently no vaccine or antiviral therapies against HRVs are available to prevent or mitigate HRV infection. There are more than 150 antigenically heterogeneous HRV serotypes, with ∼90 HRVs belonging to major group species A and B. Development of small animal models that are susceptible to infection with major group HRVs would be beneficial for vaccine research. Previously, we showed that the cotton rat (Sigmodon hispidus) is semi-permissive to HRV16 (major group, species HRV-A virus) infection, replicating in the upper and lower respiratory tracts with measurable pathology, mucus production, and expression of inflammatory mediators. Herein, we report that intranasal infection of cotton rats with HRV14 (major group, species HRV-B virus) results in isolation of infectious virus from the nose and lung. Similar to HRV16, intramuscular immunization with live HRV14 induces homologous protection that correlated with high levels of serum neutralizing antibodies. Vaccination and challenge experiments with HRV14 and HRV16 to evaluate the development of cross-protective immunity demonstrate that intramuscular immunization with live HRV16 significantly protects animals against HRV14 challenge. Determination of the immunological mechanisms involved in heterologous protection and further characterization of infection with other major HRV serotypes in the cotton rat could enhance the robustness of the model to define heterotypic relationships between this diverse group of viruses and thereby increase its potential for development of a multi-serotype HRV vaccine.
has issue date	2017-08-31(xsd:dateTime)
bibo:doi	10.3389/fmicb.2017.01646
bibo:pmid	28912760
has license	cc-by
sha1sum (hex)	7a16fe9d867203bf83dfe50ef6dd93b8e1179db7
schema:url	https://doi.org/10.3389/fmicb.2017.01646
resource representing a document's title	Immunization with Live Human Rhinovirus (HRV) 16 Induces Protection in Cotton Rats against HRV14 Infection
has PubMed Central identifier	PMC5583225
has PubMed identifier	28912760
schema:publication	Front Microbiol
resource representing a document's body	covid:7a16fe9d867203bf83dfe50ef6dd93b8e1179db7#body_text
is schema:about of	named entity 'INFECTION' named entity 'HUMAN RHINOVIRUS' named entity 'levels' named entity 'live' named entity 'upper' named entity 'live' named entity 'nose' named entity 'Protection' named entity 'Citation' named entity 'Cotton' named entity 'PATHOLOGY' named entity 'INTRAMUSCULAR' named entity 'CAUSE' named entity 'PROTECTION' named entity 'IMMUNIZATION' named entity 'B VIRUS' named entity 'NOSE' named entity 'COLD' named entity 'POTENTIAL' named entity 'HETEROLOGOUS' named entity 'MORE THAN' named entity 'EXPERIMENTS' named entity 'COTTON RAT' named entity 'CROSS' named entity 'SEROTYPE' named entity 'CURRENTLY' named entity 'HRV' named entity 'MITIGATE' named entity 'DIVERSE' named entity 'CHALLENGE' named entity 'NEUTRALIZING ANTIBODIES' named entity 'REPORT' named entity 'INFECTIOUS' named entity 'PROTECTION' named entity 'COTTON RATS' named entity 'HRV14' named entity 'LIVE' named entity 'SUSCEPTIBLE' named entity 'INTRANASAL INFECTION' named entity 'VACCINATION' named entity 'COTTON RATS' named entity 'MAIN' named entity 'RESPIRATORY TRACTS' named entity 'LUNG' named entity 'HIGH' named entity 'VIRUSES' named entity 'RELATIONSHIPS' named entity 'MECHANISMS' named entity 'VIRUS' named entity 'SEROTYPES' named entity 'INCREASE' named entity 'CORRELATED' named entity 'ITS' named entity 'HOMOLOGOUS' named entity 'EVALUATE' named entity 'REPLICATING' named entity 'LIKE' named entity 'SIMILAR' named entity 'GROUP' named entity 'MEASURABLE' named entity '150' named entity 'DEVELOPMENT' named entity 'MULTI' named entity 'VACCINE' named entity 'AVAILABLE' named entity 'HRV14' named entity 'HUMAN' named entity 'LEVELS'

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