About: The role of lipocalin-2 in age-related macular degeneration (AMD)

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About: The role of lipocalin-2 in age-related macular degeneration (AMD) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The role of lipocalin-2 in age-related macular degeneration (AMD)
Creator	Ghosh, Sayan Hose, Stacey Liu, Haitao Stepicheva, Nadezda Watson, Alan Weiss, Joseph Debasish Sinha, · Mallika Valapala, · Meysam, · Shang, · Simon, · Watkins, C Zigler, ·
topic	covid:7ac08f78949fe07162fc44ce3e37814aa36a2048#this
Source	Medline; PMC
abstract	Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00018-019-03423-8) contains supplementary material, which is available to authorized users.
has issue date	2020-01-04(xsd:dateTime)
bibo:doi	10.1007/s00018-019-03423-8
bibo:pmid	31901947
has license	no-cc
sha1sum (hex)	7ac08f78949fe07162fc44ce3e37814aa36a2048
schema:url	https://doi.org/10.1007/s00018-019-03423-8
resource representing a document's title	The role of lipocalin-2 in age-related macular degeneration (AMD)
has PubMed Central identifier	PMC7079812
has PubMed identifier	31901947
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:7ac08f78949fe07162fc44ce3e37814aa36a2048#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/7ac08f78949fe07162fc44ce3e37814aa36a2048
is schema:about of	named entity 'ROLE' named entity 'OBESITY' named entity 'PLAY' named entity 'PROBABLE' named entity 'INVOLVEMENT' named entity 'OCULAR' named entity 'IMPORTANT' named entity 'VARIOUS' named entity 'STRATEGIES' named entity 'ROLES' named entity 'MULTIPLE SCLEROSIS' named entity 'TRIGGER' named entity 'CRITICAL' named entity 'LIPOCALINS' named entity 'diseases' named entity 'LIPOCALIN-2' named entity 'LCN' named entity 'LIPOCALIN-2' named entity 'ROLE' named entity 'INCLUDING' named entity 'PROTEIN ' named entity 'CHRONIC DISEASE' named entity 'PATHOGENESIS' named entity 'DIABETES' named entity 'AGE-RELATED MACULAR DEGENERATION' named entity 'SECRETED' named entity 'FAMILY' named entity 'EXPRESSION' named entity 'STRUCTURE' named entity 'AGE-RELATED MACULAR DEGENERATION' named entity 'AMD' named entity 'DISEASES' named entity 'SIGNALING CASCADES' named entity 'ACUTE INFECTIONS' named entity 'THERAPEUTIC' named entity 'UPREGULATION' named entity 'MOLECULAR BASIS' named entity 'SUGGEST' named entity 'GENERAL' named entity 'ELABORATE' named entity 'ACUTE AND CHRONIC INFLAMMATION' named entity 'PARTICULAR' named entity 'DISCUSS' named entity 'CANCER' named entity 'PATHWAYS' named entity 'INVOLVED' named entity 'DISEASE PROGRESSION' named entity 'ADIPOKINES' named entity 'TARGETING' named entity 'BIOLOGICAL PROCESSES' named entity 'adipokines' named entity 'basis' named entity 'diabetes' named entity 'signaling cascades' named entity 'biological processes' named entity 'ocular diseases' named entity 'Lipocalin-2' named entity 'pathogenesis' named entity 'Lipocalins' named entity 'lipocalin-2' named entity 'lipocalin-2' named entity 'age-related macular degeneration' named entity 'infections' named entity 'upregulation' named entity 'obesity' named entity 'therapeutic strategies' named entity 'age-related macular degeneration'

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