About: Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens

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About: Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens
Creator	Nauwynck, Hans Theuns, Sebastiaan Li, Yewei Trus, Ivan Desmarets, Lowiese Reddy, Vishwanatha
Source	Medline; PMC
abstract	In the present study, the replication kinetics of nephropathogenic (B1648) and respiratory (Massachusetts-M41) IBV strains were compared in vitro in respiratory mucosa explants and blood monocytes (KUL01(+) cells), and in vivo in chickens to understand why some IBV strains have a kidney tropism. B1648 was replicating somewhat better than M41 in the epithelium of the respiratory mucosa explants and used more KUL01(+) cells to penetrate the deeper layers of the respiratory tract. B1648 was productively replicating in KUL01(+) monocytic cells in contrast with M41. In B1648 inoculated animals, 10(2.7–6.8) viral RNA copies/100 mg were detected in tracheal secretions at 2, 4, 6, 8, 10 and 12 days post inoculation (dpi), 10(2.4–4.5) viral RNA copies/mL in plasma at 2, 4, 6, 8, 10 and 12 dpi and 10(1.8–4.4) viral RNA copies/10(6) mononuclear cells in blood at 2, 4, 6 and 8 dpi. In M41 inoculated animals, 10(2.6–7.0) viral RNA copies/100 mg were detected in tracheal secretions at 2, 4, 6, 8 and 10 dpi, but viral RNA was not demonstrated in plasma and mononuclear cells (except in one chicken at 6 dpi). Infectious virus was detected only in plasma and mononuclear cells of the B1648 group. At euthanasia (12 dpi), viral RNA and antigen positive cells were detected in lungs, liver, spleen and kidneys of only the B1648 group and in tracheas of both the B1648 and M41 group. In conclusion, only B1648 can easily disseminate to internal organs via a cell-free and -associated viremia with KUL01(+) cells as important carrier cells.
has issue date	2016-07-13(xsd:dateTime)
bibo:doi	10.1186/s13567-016-0354-9
bibo:pmid	27412035
has license	cc-by
sha1sum (hex)	7acba31dde3af3dc1bedbde1c8167ad802fbf43e
schema:url	https://doi.org/10.1186/s13567-016-0354-9
resource representing a document's title	Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens
has PubMed Central identifier	PMC4944500
has PubMed identifier	27412035
schema:publication	Vet Res
resource representing a document's body	covid:7acba31dde3af3dc1bedbde1c8167ad802fbf43e#body_text
is schema:about of	named entity 'cells' named entity 'chickens' named entity 'strains' named entity 'explants' named entity 'replication' named entity 'chickens' named entity 'CELLS' named entity 'PERIPHERAL BLOOD' named entity 'EPITHELIUM' named entity 'KINETICS' named entity 'BLOOD MONOCYTES' named entity 'CHICKENS' named entity 'REPLICATION' named entity 'SOMEWHAT BETTER' named entity 'HAVE' named entity 'RESPIRATORY' named entity 'TROPISM' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'PRODUCTIVE' named entity 'MONOCYTIC' named entity 'KIDNEY INFECTION' named entity 'REPLICATION' named entity 'IN VIVO' named entity 'PENETRATE' named entity 'STRAINS' named entity 'RESPIRATORY TRACT' named entity 'REPLICATING' named entity 'COMPARED' named entity 'KIDNEY' named entity 'M41' named entity 'B1648' named entity 'WHY' named entity 'RESPIRATORY MUCOSA' named entity 'IN VITRO' named entity 'LAYERS' named entity 'USED' named entity 'CELLS' named entity 'VIRAL' named entity 'PRESENT' named entity 'STUDY' named entity 'UNDERSTAND' named entity 'CHICKENS' named entity 'IBV' named entity 'DISSEMINATION' named entity 'STRATEGY' covid:arg/7acba31dde3af3dc1bedbde1c8167ad802fbf43e named entity 'vivo' named entity 'respiratory mucosa' named entity 'epithelium' named entity 'peripheral blood' named entity 'explants' named entity 'tropism' named entity 'respiratory tract' named entity 'kinetics' named entity 'respiratory mucosa' named entity 'explants' named entity 'epithelium' named entity 'infectious bronchitis virus' named entity 'IBV' named entity 'URT' named entity 'mononuclear cells' named entity 'genus' named entity 'IBV' named entity 'spleen' named entity 'monocytic' named entity 'Belgium' named entity 'body weight' named entity 'mononuclear cells' named entity 'lamina propria' named entity 'mucosa' named entity 'DMEM' named entity 'evolutionary relationship' named entity 'virus' named entity 'IBV' named entity 'dengue virus' named entity 'mononuclear cells'

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