About: Clinical Efficacy of Intravenous Hypertonic Saline Solution or Hypertonic Bicarbonate Solution in the Treatment of Inappetent Calves with Neonatal Diarrhea

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About: Clinical Efficacy of Intravenous Hypertonic Saline Solution or Hypertonic Bicarbonate Solution in the Treatment of Inappetent Calves with Neonatal Diarrhea Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical Efficacy of Intravenous Hypertonic Saline Solution or Hypertonic Bicarbonate Solution in the Treatment of Inappetent Calves with Neonatal Diarrhea
Creator	Koch, A Kaske, M
Source	Medline; PMC
abstract	Background: The clinical efficacy of IV administered hypertonic saline solution and hypertonic bicarbonate solution (HBS) in the treatment of inappetent diarrheic calves has not been compared yet. Hypothesis: HBS is more advantageous than hypertonic saline in the treatment of calves with severe metabolic acidosis. Animals: Twenty‐eight dehydrated, inappetent calves with neonatal diarrhea. Methods: In 2 consecutive clinical studies, calves were initially treated with saline (5.85%; 5 mL/kg body weight [BW] over 4 minutes; study I: N = 16) or bicarbonate solution (8.4%; 10 mL/kg BW over 8 minutes; study II: N = 12), respectively, followed by oral administration of 3 L isotonic electrolyte solution 5 minutes after injection. Clinical and laboratory variables were monitored for 72 hours. Results: Treatment failed in 6 calves of study I and in 1 calf of study II as indicated by a deterioration of the general condition. All treatment failures had more severe metabolic acidosis compared with successfully treated calves before treatment. In the latter, rehydration was completed within 18 hours after injection; metabolic acidosis was corrected within 24 hours (study I) and 6 hours (study II) after injection. Conclusions and Clinical Importance: Diarrheic calves with slight metabolic acidosis (base excess [BE] >−10 mM) can be treated successfully with hypertonic saline. HBS is appropriate in calves without respiratory problems with more severe metabolic acidosis (BE up to −20 mM). Intensive care of the calves is required to ensure a sufficient oral fluid intake after the initial IV treatment.
has issue date	2008-02-14(xsd:dateTime)
bibo:doi	10.1111/j.1939-1676.2007.0029.x
bibo:pmid	18289311
has license	no-cc
sha1sum (hex)	7c2a10120e33a16754606e8b8277b14cccc3aa6f
schema:url	https://doi.org/10.1111/j.1939-1676.2007.0029.x
resource representing a document's title	Clinical Efficacy of Intravenous Hypertonic Saline Solution or Hypertonic Bicarbonate Solution in the Treatment of Inappetent Calves with Neonatal Diarrhea
has PubMed Central identifier	PMC7166734
has PubMed identifier	18289311
schema:publication	J Vet Intern Med
resource representing a document's body	covid:7c2a10120e33a16754606e8b8277b14cccc3aa6f#body_text
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