About: Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert–isolated rare actinomycete Nocardia sp. XJ31

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About: Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert–isolated rare actinomycete Nocardia sp. XJ31 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert–isolated rare actinomycete Nocardia sp. XJ31
Creator	Wang, Jian Zhang, Li Li, Jin-Ping Ma, Rong Ren, Biao Zhang, Jingyu Liu, Zhiheng Liu, Mei Dai, Huanqin Ding, Kan Hou, Chengjian Liu, Xueting Lu, Wanying Ma, Xiaolong Zhang, Lixin
source	Medline; PMC
abstract	ABSTRACT: The current global demand for novel anti-TB drugs has drawn urgent attention on the discovery of natural product compounds with anti-TB activity. Lots of efforts have emphasized on environmental samples from unexplored or underexplored natural habits and identified numerous rare actinomycete taxa producing structurally diverse bioactive natural products. Herein, we report a survey of the rare actinobacteria diversity in Xinjiang region together with the discovery of anti-TB active natural products from these strains. We have collected 17 soil samples at different sites with different environmental conditions, from which 39 rare actinobacteria were identified by using a selective isolation strategy with 5 media variations. Among those isolated strains, XJ31 was identified as a new Nocardia sp. based on 16S rRNA gene analysis. Through one strain-many compounds (OSMAC) strategy combined with anti-Bacillus Calmette-Guérin bioassay-guided isolation, two groups of compounds were identified. They were twelve siderophores (nocardimicins, 1-12) and two anthraquinones (brasiliquinones, 13 and 14) and ten of them were identified as new compounds. The structures of the purified compounds were elucidated using HR-ESI-MS, 1D NMR, and 2D NMR techniques. The anti-TB bioassays revealed that the two benz[α]anthraquinones have potent activity against BCG (MICs = 25 μM), which can be used as a promising start point for further anti-TB drug development. KEY POINTS: • Ten new natural products were identified from Nocardia sp. XJ31. • Brasiliquinones 13 and 14 showed moderate anti-BCG activity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00253-020-10842-2) contains supplementary material, which is available to authorized users.
has issue date	2020-08-24(xsd:dateTime)
bibo:doi	10.1007/s00253-020-10842-2
bibo:pmid	32830291
has license	no-cc
sha1sum (hex)	7c6ee07abaeb42b4923cc0bdc29cdb00078d60e3
schema:url	https://doi.org/10.1007/s00253-020-10842-2
resource representing a document's title	Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert–isolated rare actinomycete Nocardia sp. XJ31
has PubMed Central identifier	PMC7443361
has PubMed identifier	32830291
schema:publication	Appl Microbiol Biotechnol
resource representing a document's body	covid:7c6ee07abaeb42b4923cc0bdc29cdb00078d60e3#body_text
is schema:about of	named entity 'revealed' named entity 'identified' named entity 'anthraquinones' named entity 'TECHNIQUES' named entity 'DIFFERENT' named entity 'BACILLUS' named entity 'START POINT' named entity 'identified' named entity 'anthraquinones' named entity 'actinobacteria' named entity 'compounds' named entity 'compounds' named entity 'discovery' named entity 'compounds' named entity 'survey' named entity 'selective' named entity 'isolation' named entity 'natural products' named entity 'environmental conditions' named entity 'Xinjiang' named entity 'actinobacteria' named entity 'anti-TB drugs' named entity 'gene analysis' named entity 'MICs' named entity 'benz' named entity 'Nocardia' named entity 'Nocardia' named entity 'supernatant' named entity 'NMR spectra' named entity 'MeOH' named entity 'NPs' named entity 'siderophores' named entity 'NMR spectra' named entity 'Agilent' named entity 'Nocardia brasiliensis' named entity 'H NMR' named entity '5.7' named entity 'bioassays' named entity 'antibiotics' named entity 'BCG' named entity 'gradient elution' named entity 'nucleotide sequences' named entity 'siderophores' named entity 'capreomycin' named entity 'conjugated' named entity 'HPLC' named entity 'molecular formula' named entity 'genus' named entity 'HPLC' named entity 'inhibitory activity' named entity 'NCBI' named entity 'siderophores' named entity 'HMBC' named entity 'long-term' named entity 'Dover' named entity 'actinobacteria' named entity 'Thermal Cycler' named entity 'siderophore' named entity 'isocratic' named entity 'Saccharopolyspora' named entity 'M. bovis' named entity 'isopropanol' named entity 'chemical compounds' named entity 'UV absorption' named entity 'polymerase' named entity 'hydroxamates' named entity 'C-7'

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